Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

20%: weighted overlap
20: shared signals

First condition

Second condition

Comparison

Type 2 DiabetesandLong COVID

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

30: Type 2 Diabetes references
18: Long COVID references
0: shared references

Metals elevated or accumulated

1 shared

Metals depleted or redistributed

1 shared

Shared

Glutathione (GSH)

Only in Type 2 Diabetes

Zinc Chromium Magnesium Manganese

Only in Long COVID

Iron Selenium Copper Nickel

Taxa enriched

5 shared

Shared

Escherichia coli Enterobacteriaceae Streptococcus Enterococcus Candida albicans

Only in Type 2 Diabetes

Prevotella Helicobacter pylori Campylobacter jejuni

Only in Long COVID

Veillonella Fusobacterium nucleatum Aspergillus Klebsiella pneumoniae

Taxa depleted

5 shared

Shared

Faecalibacterium prausnitzii Bifidobacterium Akkermansia muciniphila Lachnospiraceae Roseburia

Only in Type 2 Diabetes

Ruminococcus Bacteroides fragilis Blautia

Only in Long COVID

Lactobacillus

Host response elevated

3 shared

Shared

Hepcidin TNF-alpha (Tumor Necrosis Factor Alpha)IL 6

Only in Type 2 Diabetes

LipopolysaccharideInflammatory CytokinesFerritin Ceruloplasmin

Only in Long COVID

IL-1beta (Interleukin-1 Beta)IFN-gamma (Interferon Gamma)LPS In CirculationPD 1 On CD8TIM 3 On CD8AutoantibodiesCalprotectin (S100A8/A9)Zinc In Secretions

Host response depleted

2 shared

Shared

Butyrate Glutathione (GSH)

Only in Type 2 Diabetes

PropionateAcetateBile AcidsZinc Chromium Manganese Magnesium

Only in Long COVID

Regulatory T CellsNK Cell FunctionMemory B CellsSIgASeleniumIron In Tissues

Ecological state

1 shared

Shared

SCFA Depletion

Only in Type 2 Diabetes

DysbiosisLPS ElevationBile Acid DysmetabolismImpaired Intestinal BarrierLipid PeroxidationReduced Microbial DiversityEndotoxemiaGut Barrier DisruptionBile Acid DysregulationIron Overload Oxidative StressFungal Overgrowth

Only in Long COVID

Self Perpetuating Dysbiosis LoopAnaerobe To Aerobe ShiftSCFA CollapseBacterial Translocation EndotoxemiaGut Lung Axis DisruptionGut Brain Axis DisruptionTryptophan AhR DysmetabolismVirome Co DysbiosisMulti Kingdom DysbiosisNon Linear Recovery TrajectoryStrain Level Diversity CollapseEstrobolome DysfunctionUremic Metabolite AccumulationHypoxia CellularAerobe BloomBarrier DysfunctionBacterial TranslocationMulti Kingdom Co DysbiosisNon Linear Recovery

Virulence and functional enzymes

2 shared

Shared

SiderophoresLPS Biosynthesis Enzymes

Only in Type 2 Diabetes

LipopolysaccharideCholine TMA LyaseBile Acid DehydrataseCarbohydrate Fermentation EnzymesNickel-UreaseTMA Lyase CutC CutD

Only in Long COVID

LPS Synthesis TransportAdhesion Invasion FactorsBile Salt Hydrolase (BSH)Beta-GlucuronidasePolysaccharide DegradationBeta Lactamases