Comparative evidence
Compare conditions
Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.
- 21%
- weighted overlap
- 20
- shared signals
Comparison
Type 2 DiabetesandDepression
5 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.
- 30
- Type 2 Diabetes references
- 38
- Depression references
- 5
- shared references
Metals depleted or redistributed
2 sharedTaxa enriched
3 sharedShared
Only in Type 2 Diabetes
Only in Depression
Taxa depleted
3 sharedShared
Only in Type 2 Diabetes
Only in Depression
Host response elevated
3 sharedHost response depleted
3 sharedEcological state
3 sharedShared
Only in Type 2 Diabetes
LPS ElevationBile Acid DysmetabolismImpaired Intestinal BarrierLipid PeroxidationReduced Microbial DiversityGut Barrier DisruptionBile Acid DysregulationIron Overload Oxidative StressFungal Overgrowth
Only in Depression
Leaky GutIntestinal PermeabilityLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation
Virulence and functional enzymes
1 sharedShared
LPS Biosynthesis Enzymes
Only in Type 2 Diabetes
LipopolysaccharideCholine TMA LyaseBile Acid DehydrataseCarbohydrate Fermentation EnzymesSiderophoresNickel-UreaseTMA Lyase CutC CutD
Only in Depression
TryptophanaseBeta-GlucuronidaseLPS BiosynthesisPro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseBacterial Amyloids Curli