Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

7%: weighted overlap
7: shared signals

First condition

Second condition

Comparison

Type 1 DiabetesandNecrotizing Enterocolitis

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

20: Type 1 Diabetes references
19: Necrotizing Enterocolitis references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Iron

Only in Type 1 Diabetes

Cadmium Lead Arsenic Copper

Only in Necrotizing Enterocolitis

None indexed

Metals depleted or redistributed

1 shared

Shared

Zinc

Only in Type 1 Diabetes

Glutathione (GSH)Selenium

Only in Necrotizing Enterocolitis

None indexed

Taxa enriched

1 shared

Shared

Escherichia coli

Only in Type 1 Diabetes

Bacteroides Ruminococcus gnavus Streptococcus Veillonella Enterobacteriaceae Sutterella Akkermansia muciniphila Prevotellaceae

Only in Necrotizing Enterocolitis

Klebsiella Clostridium perfringens Staphylococcus Klebsiella pneumoniaeClostridium Perfringens (Toxigenic)Sphingomonas Spp.Clostridium Spp. (Obligate Anaerobe Cluster)Bacteroides/Prevotella (Obligate Anaerobe Cluster)Staphylococcus epidermidis Enterococcus

Taxa depleted

2 shared

Shared

Bifidobacterium Lactobacillus

Only in Type 1 Diabetes

Faecalibacterium prausnitzii Roseburia Subdoligranulum Eubacterium rectale Prevotella LachnospiraceaeClostridium Clusters IV/XIVaBlautia Eubacterium eligens Clostridium

Only in Necrotizing Enterocolitis

BacteroidesBacteroidetes (Phylum)

Host response elevated

0 shared

Shared

None indexed

Only in Type 1 Diabetes

ZnT8 AutoantibodiesGADAIA 2AInsulin AutoantibodiesType 1 IFN SignatureTLR4 NF KB ActivationHepcidin FerritinAnti ZnT8 Autoantibodies

Only in Necrotizing Enterocolitis

Calprotectin (S100A8/A9)Lactoferrin EndogenousPro Inflammatory CytokinesTLR4 ExpressionLPSTNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)IL 6

Host response depleted

1 shared

Shared

Zinc

Only in Type 1 Diabetes

Glutathione (GSH)Treg FunctionGPR43 SCFA SignalingZinc BioavailabilityMetallothionein

Only in Necrotizing Enterocolitis

Defensins AcetateLactateSecretory IgA

Ecological state

0 shared

Shared

None indexed

Only in Type 1 Diabetes

Butyrate SCFA Ratio ShiftLeaky Gut Precedes OnsetBacterial Translocation To PLNMucin Layer ThinningImmunoinhibitory LPSCVB4 Microbiome SynergyTwo Step Temporal ModelMicrobiome Changes Precede AutoantibodiesBacteroidetes Firmicutes Ratio InversionGut Barrier CompromiseLPS Translocation To PLNSCFA GPR43 Axis DisruptionTreg DepletionViral Dysbiosis TriggerDevelopmental Vulnerability Window

Only in Necrotizing Enterocolitis

Proteobacteria Bloom 2 Weeks Pre DiagnosisVirome Convergence 10 Days Pre OnsetTLR4 Upregulation In Premature EpitheliumBifidobacterium Absence As PreconditionHMO Mediated Colonization ResistanceFeed Forward Barrier DestructionProteobacteria BloomTLR4 Feed Forward LoopVirome ConvergenceImmature BarrierParenteral Iron OverloadBiofilmBile Acid Accumulation ASBT UpregulationMuc2 Depletion Mucosal Barrier FailureObligate Anaerobe Mucosal InvasionGut Brain Axis NDI RiskAntibiotic Driven Richness Nadir Week4

Virulence and functional enzymes

1 shared

Shared

LPS Biosynthesis

Only in Type 1 Diabetes

LPS Biosynthesis GenesIron Acquisition FecB IsdDEFType VI Secretion SystemsDNA Adenine MethyltransferasesBeta-Glucuronidase

Only in Necrotizing Enterocolitis

SiderophoresAlpha ToxinPerfringolysin OBiofilm Formation Enzymes