Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

10%: weighted overlap
8: shared signals

First condition

Second condition

Comparison

SchizophreniaandBarrett's Esophagus

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

46: Schizophrenia references
7: Barrett's Esophagus references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Iron

Only in Schizophrenia

Copper Lead Cadmium Arsenic

Only in Barrett's Esophagus

None indexed

Metals depleted or redistributed

1 shared

Taxa enriched

3 shared

Shared

Prevotella Enterobacteriaceae Veillonella

Only in Schizophrenia

Lactobacillus StreptococcusSuccinivibrioCandida albicansTrichosporonPurpureocillium Clostridia Betaproteobacteria Prevotellaceae

Only in Barrett's Esophagus

Leptotrichia Fusobacterium nucleatum Faecalibacterium prausnitzii Klebsiella pneumoniae

Taxa depleted

1 shared

Shared

Bifidobacterium

Only in Schizophrenia

Faecalibacterium prausnitzii Roseburia Coprococcus Blautia Saccharomyces cerevisiae Desulfovibrio Veillonellaceae Lachnospiraceae

Only in Barrett's Esophagus

Streptococcus Akkermansia muciniphila Lactobacillus

Host response elevated

1 shared

Shared

IL 6

Only in Schizophrenia

CRPSCD14IL-1beta (Interleukin-1 Beta)TNF-alpha (Tumor Necrosis Factor Alpha)IL-8 (Interleukin-8 / CXCL8)IL 12TGF-beta (Transforming Growth Factor Beta)NLRP3 InflammasomeComplement C4AMalondialdehydeCeruloplasmin Bound CopperCeruloplasmin Hepcidin Lipocalin-2 ZonulinAlpha 1 Antitrypsin

Only in Barrett's Esophagus

Tlr4 LigandsNf KbLps

Host response depleted

0 shared

Shared

None indexed

Only in Schizophrenia

Glutathione (GSH)Total Antioxidant CapacityVitamin DAnti Inflammatory CytokinesSCFAsZinc Finger Proteins

Only in Barrett's Esophagus

Claudin 1

Ecological state

0 shared

Shared

None indexed

Only in Schizophrenia

SCFA DepletionGut Barrier DysfunctionTryptophan Kynurenine ShuntingTranskingdom Network DisruptionOral Gut Axis H2S EnrichmentMulti Kingdom DysbiosisMetabolic Syndrome ComorbidityGut Barrier DisruptionMicroglial ActivationTh17 Treg ImbalanceVirome Dysbiosis

Only in Barrett's Esophagus

Gram Negative Anaerobe DominanceType II MicrobiomeIntestinal MetaplasiaAneuploidyOral Esophageal TranslocationH Pylori Paradoxical ProtectionProgressive Prevotella Gradient

Virulence and functional enzymes

1 shared

Shared

LPS Biosynthesis

Only in Schizophrenia

Tryptophan Catabolism EnzymesH2S Producing Enzyme SystemsSiderophore SystemsBeta-GlucuronidaseIndoleamine 2 3 DioxygenaseTryptophanase

Only in Barrett's Esophagus

TonB Iron TransportMlaD Membrane Lipid AsymmetryBacterial Proteases