Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

23%: weighted overlap
20: shared signals

First condition

Second condition

Comparison

Postpartum DepressionandDepression

7 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

56: Postpartum Depression references
38: Depression references
7: shared references

Metals elevated or accumulated

3 shared

Shared

Copper Cadmium Lead

Only in Postpartum Depression

None indexed

Only in Depression

Mercury

Metals depleted or redistributed

3 shared

Taxa enriched

2 shared

Shared

Enterobacteriaceae Escherichia coli

Only in Postpartum Depression

AlphaproteobacteriaBilophila Desulfovibrio Dialister Enterococcus

Only in Depression

Candida albicans Clostridium Bacteroides fragilis Eggerthella Flavonifractor

Taxa depleted

4 shared

Shared

Bifidobacterium Faecalibacterium prausnitzii Lachnospiraceae Coprococcus

Only in Postpartum Depression

Phascolarctobacterium Veillonella Eubacterium Clostridium Butyricicoccus Holdemanella

Only in Depression

Prevotella Dialister Lactobacillus

Host response elevated

2 shared

Shared

Hepcidin Ceruloplasmin

Only in Postpartum Depression

IL 6CRPTNF-alpha (Tumor Necrosis Factor Alpha)IDOCopper

Only in Depression

Calprotectin (S100A8/A9)Pro Inflammatory CytokinesFerritin

Host response depleted

2 shared

Shared

Zinc Selenium

Only in Postpartum Depression

Tryptophan GABA (Gamma-Aminobutyric Acid)SCFAFerritin

Only in Depression

Magnesium Iron Glutathione (GSH)Glutathione Peroxidase

Ecological state

2 shared

Shared

SCFA DepletionHPA Axis Dysregulation

Only in Postpartum Depression

Postpartum Hormonal CrashEstrogen Progesterone WithdrawalIDO Kynurenine ActivationTryptophan DiversionGut Brain Axis DisruptionBile Acid DysmetabolismPrenatal Microbiome SeedingIntergenerational Dysbiosis TransmissionBarrier DysfunctionHormonal DysregulationTryptophan Kynurenine ShuntingIntergenerational Microbiome Transmission

Only in Depression

DysbiosisLeaky GutIntestinal Permeability EndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionTryptophan Shunting IDOHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation

Virulence and functional enzymes

2 shared

Shared

Beta-GlucuronidaseLPS Biosynthesis Enzymes

Only in Postpartum Depression

LPS EndotoxinIDO Indoleamine 2 3 DioxygenaseBile Salt Hydrolase (BSH)Sulfite ReductaseSiderophores EnterobactinSiderophores

Only in Depression

TryptophanaseLPS BiosynthesisPro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseBacterial Amyloids Curli