Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

7%: weighted overlap
7: shared signals

First condition

Second condition

Comparison

Premenstrual Dysphoric DisorderandLong COVID

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

6: Premenstrual Dysphoric Disorder references
18: Long COVID references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Premenstrual Dysphoric Disorder

Copper

Only in Long COVID

Zinc Arsenic Thallium

Metals depleted or redistributed

0 shared

Shared

None indexed

Only in Premenstrual Dysphoric Disorder

Magnesium Zinc

Only in Long COVID

Iron Selenium Copper Nickel Glutathione (GSH)

Taxa enriched

1 shared

Shared

Escherichia coli

Only in Premenstrual Dysphoric Disorder

Anaerotaenia

Only in Long COVID

Enterobacteriaceae Streptococcus Enterococcus Veillonella Candida albicans Fusobacterium nucleatum Aspergillus Klebsiella pneumoniae

Taxa depleted

1 shared

Host response elevated

1 shared

Shared

TNF-alpha (Tumor Necrosis Factor Alpha)

Only in Premenstrual Dysphoric Disorder

IL-8 (Interleukin-8 / CXCL8)Pro Inflammatory CytokinesCopper Zinc Ratio

Only in Long COVID

IL 6IL-1beta (Interleukin-1 Beta)IFN-gamma (Interferon Gamma)LPS In CirculationPD 1 On CD8TIM 3 On CD8AutoantibodiesHepcidin Calprotectin (S100A8/A9)Zinc In Secretions

Host response depleted

1 shared

Shared

Butyrate

Only in Premenstrual Dysphoric Disorder

Magnesium Serotonin GABA (Gamma-Aminobutyric Acid)Allopregnanolone Sensitivity

Only in Long COVID

Regulatory T CellsNK Cell FunctionMemory B CellsSIgAGlutathione (GSH)SeleniumIron In Tissues

Ecological state

2 shared

Shared

Estrobolome DysfunctionSCFA Depletion

Only in Premenstrual Dysphoric Disorder

Tryptophan Kynurenine ShuntingGABA A Receptor ModulationLuteal Phase InflammationBeta Glucuronidase DysregulationEstrogen RecirculationBeta Glucuronidase ActivityCircadian Rhythm DisruptionMelatonin Amplitude Reduction

Only in Long COVID

Self Perpetuating Dysbiosis LoopAnaerobe To Aerobe ShiftSCFA CollapseBacterial Translocation EndotoxemiaGut Lung Axis DisruptionGut Brain Axis DisruptionTryptophan AhR DysmetabolismVirome Co DysbiosisMulti Kingdom DysbiosisNon Linear Recovery TrajectoryStrain Level Diversity CollapseUremic Metabolite AccumulationHypoxia CellularAerobe BloomBarrier DysfunctionBacterial TranslocationMulti Kingdom Co DysbiosisNon Linear Recovery

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Premenstrual Dysphoric Disorder

TryptophanaseIDO UpregulationLPS BiosynthesisIndoleamine 2 3 Dioxygenase

Only in Long COVID

LPS Synthesis TransportSiderophoresAdhesion Invasion FactorsBile Salt Hydrolase (BSH)Polysaccharide DegradationLPS Biosynthesis EnzymesBeta Lactamases