Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

28%: weighted overlap
23: shared signals

First condition

Second condition

Comparison

ObesityandType 2 Diabetes

6 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

31: Obesity references
30: Type 2 Diabetes references
6: shared references

Metals elevated or accumulated

4 shared

Metals depleted or redistributed

2 shared

Shared

Glutathione (GSH)Magnesium

Only in Obesity

Barium Vanadium Titanium

Only in Type 2 Diabetes

Zinc Chromium Manganese

Taxa enriched

3 shared

Shared

Escherichia coli Streptococcus Enterobacteriaceae

Only in Obesity

Fusobacterium Bacteroides fragilis

Only in Type 2 Diabetes

Prevotella Enterococcus Candida albicans Helicobacter pylori Campylobacter jejuni

Taxa depleted

5 shared

Shared

Faecalibacterium prausnitzii Roseburia Lachnospiraceae Akkermansia muciniphila Bifidobacterium

Only in Obesity

Oscillospiraceae

Only in Type 2 Diabetes

Ruminococcus Bacteroides fragilis Blautia

Host response elevated

2 shared

Shared

Hepcidin Ferritin

Only in Obesity

Calprotectin (S100A8/A9)Transferrin Lipocalin-2 Lactoferrin

Only in Type 2 Diabetes

LipopolysaccharideInflammatory CytokinesTNF-alpha (Tumor Necrosis Factor Alpha)IL 6Ceruloplasmin

Host response depleted

2 shared

Shared

Glutathione (GSH)Butyrate

Only in Obesity

Short-Chain Fatty Acids (SCFAs)

Only in Type 2 Diabetes

PropionateAcetateBile AcidsZinc Chromium Manganese Magnesium

Ecological state

3 shared

Shared

EndotoxemiaReduced Microbial DiversityBile Acid Dysregulation

Only in Obesity

HypoxiaMetal Driven DysbiosisReduced SCFA ProductionIncreased LPSIntestinal Permeability IncreaseFermentative Metabolism Acidic MicroenvironmentMetabolic EndotoxemiaIncreased Energy HarvestVirome Depletion

Only in Type 2 Diabetes

DysbiosisSCFA DepletionLPS ElevationBile Acid DysmetabolismImpaired Intestinal BarrierLipid PeroxidationGut Barrier DisruptionIron Overload Oxidative StressFungal Overgrowth

Virulence and functional enzymes

2 shared

Shared

Siderophores Nickel-Urease

Only in Obesity

TMA LyaseNickel HydrogenaseZinc MetalloproteasesLPS BiosynthesisBeta-Glucuronidase

Only in Type 2 Diabetes

LipopolysaccharideCholine TMA LyaseBile Acid DehydrataseCarbohydrate Fermentation EnzymesLPS Biosynthesis EnzymesTMA Lyase CutC CutD