Comparative evidence
Compare conditions
Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.
- 19%
- weighted overlap
- 16
- shared signals
Comparison
ObesityandDepression
2 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.
- 31
- Obesity references
- 38
- Depression references
- 2
- shared references
Metals depleted or redistributed
1 sharedTaxa enriched
3 sharedShared
Only in Obesity
Only in Depression
Taxa depleted
3 sharedShared
Only in Obesity
Only in Depression
Host response elevated
3 sharedHost response depleted
1 sharedShared
Only in Obesity
Only in Depression
Ecological state
1 sharedShared
Only in Obesity
HypoxiaMetal Driven DysbiosisReduced SCFA ProductionIncreased LPSIntestinal Permeability IncreaseFermentative MetabolismAcidic MicroenvironmentMetabolic EndotoxemiaReduced Microbial DiversityIncreased Energy HarvestBile Acid DysregulationVirome Depletion
Only in Depression
DysbiosisLeaky GutIntestinal PermeabilityLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOSCFA DepletionHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation
Virulence and functional enzymes
2 sharedShared
LPS BiosynthesisBeta-Glucuronidase
Only in Obesity
Only in Depression
TryptophanasePro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli