Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

13%: weighted overlap
14: shared signals

First condition

Second condition

Comparison

ObesityandAutism Spectrum Disorder

1 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

31: Obesity references
32: Autism Spectrum Disorder references
1: shared references

Metals elevated or accumulated

3 shared

Metals depleted or redistributed

1 shared

Shared

Glutathione (GSH)

Only in Obesity

Magnesium Barium Vanadium Titanium

Only in Autism Spectrum Disorder

Zinc Iron Selenium

Taxa enriched

0 shared

Shared

None indexed

Only in Obesity

Escherichia coli Streptococcus Enterobacteriaceae Fusobacterium Bacteroides fragilis

Only in Autism Spectrum Disorder

Bacteroides Parabacteroides ClostridiumEubacterium CoprostanoligenesDesulfovibrio

Taxa depleted

3 shared

Shared

Faecalibacterium prausnitzii Lachnospiraceae Bifidobacterium

Only in Obesity

Roseburia Akkermansia muciniphila Oscillospiraceae

Only in Autism Spectrum Disorder

Coprococcus Lactobacillus

Host response elevated

5 shared

Shared

Hepcidin Calprotectin (S100A8/A9)Transferrin Lipocalin-2 Lactoferrin

Only in Obesity

Ferritin

Only in Autism Spectrum Disorder

TNF-alpha (Tumor Necrosis Factor Alpha)IL 1IL 6IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)NF KappaBMalondialdehydeFolate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Obesity

Butyrate Short-Chain Fatty Acids (SCFAs)

Only in Autism Spectrum Disorder

SulfateZinc IL-10 (Interleukin-10)TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx ActivityCu Zn SOD

Ecological state

0 shared

Shared

None indexed

Only in Obesity

HypoxiaMetal Driven DysbiosisReduced SCFA ProductionIncreased LPSEndotoxemiaIntestinal Permeability IncreaseFermentative Metabolism Acidic MicroenvironmentMetabolic EndotoxemiaReduced Microbial DiversityIncreased Energy HarvestBile Acid DysregulationVirome Depletion

Only in Autism Spectrum Disorder

Gut Barrier DysfunctionPropionic Acid NeurotoxicityOxidative StressBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalGut Barrier DisruptionMis-MetallationPropionic Acid ElevationSCFA ImbalanceNeuroinflammationDevelopmental Vulnerability

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Obesity

TMA LyaseSiderophores Nickel-UreaseNickel HydrogenaseZinc MetalloproteasesLPS Biosynthesis

Only in Autism Spectrum Disorder

ALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production