Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

9%: weighted overlap
9: shared signals

First condition

Second condition

Comparison

Necrotizing EnterocolitisandDepression

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

19: Necrotizing Enterocolitis references
38: Depression references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Necrotizing Enterocolitis

Iron

Only in Depression

Cadmium Lead Mercury Copper

Metals depleted or redistributed

1 shared

Shared

Zinc

Only in Necrotizing Enterocolitis

None indexed

Only in Depression

Magnesium Iron Selenium

Taxa enriched

1 shared

Shared

Escherichia coli

Only in Necrotizing Enterocolitis

Klebsiella Clostridium perfringens Staphylococcus Klebsiella pneumoniaeClostridium Perfringens (Toxigenic)Sphingomonas Spp.Clostridium Spp. (Obligate Anaerobe Cluster)Bacteroides/Prevotella (Obligate Anaerobe Cluster)Staphylococcus epidermidis Enterococcus

Only in Depression

Candida albicans Clostridium Bacteroides fragilis Eggerthella Enterobacteriaceae Flavonifractor

Taxa depleted

2 shared

Shared

Bifidobacterium Lactobacillus

Only in Necrotizing Enterocolitis

BacteroidesBacteroidetes (Phylum)

Only in Depression

Faecalibacterium prausnitzii Lachnospiraceae Prevotella Coprococcus Dialister

Host response elevated

2 shared

Shared

Calprotectin (S100A8/A9)Pro Inflammatory Cytokines

Only in Necrotizing Enterocolitis

Lactoferrin EndogenousTLR4 ExpressionLPSTNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)IL 6

Only in Depression

Hepcidin Ceruloplasmin Ferritin

Host response depleted

1 shared

Shared

Zinc

Only in Necrotizing Enterocolitis

Defensins AcetateLactateSecretory IgA

Only in Depression

Magnesium Iron Selenium Glutathione (GSH)Glutathione Peroxidase

Ecological state

0 shared

Shared

None indexed

Only in Necrotizing Enterocolitis

Proteobacteria Bloom 2 Weeks Pre DiagnosisVirome Convergence 10 Days Pre OnsetTLR4 Upregulation In Premature EpitheliumBifidobacterium Absence As PreconditionHMO Mediated Colonization ResistanceFeed Forward Barrier DestructionProteobacteria BloomTLR4 Feed Forward LoopVirome ConvergenceImmature BarrierParenteral Iron OverloadBiofilmBile Acid Accumulation ASBT UpregulationMuc2 Depletion Mucosal Barrier FailureObligate Anaerobe Mucosal InvasionGut Brain Axis NDI RiskAntibiotic Driven Richness Nadir Week4

Only in Depression

DysbiosisLeaky GutIntestinal Permeability EndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOSCFA DepletionHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation

Virulence and functional enzymes

2 shared

Shared

LPS BiosynthesisBiofilm Formation Enzymes

Only in Necrotizing Enterocolitis

SiderophoresAlpha ToxinPerfringolysin O

Only in Depression

TryptophanaseBeta-GlucuronidasePro Inflammatory Metabolite SynthesisIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli