Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

19%: weighted overlap
18: shared signals

First condition

Second condition

Comparison

Hashimoto's ThyroiditisandAlzheimer's Disease

1 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

17: Hashimoto's Thyroiditis references
31: Alzheimer's Disease references
1: shared references

Metals elevated or accumulated

5 shared

Shared

Cadmium Lead Mercury Nickel Copper

Only in Hashimoto's Thyroiditis

Iodine Excess

Only in Alzheimer's Disease

Arsenic Manganese Iron AluminumZinc In Plaques

Metals depleted or redistributed

2 shared

Taxa enriched

3 shared

Shared

Prevotella Akkermansia muciniphila Klebsiella pneumoniae

Only in Hashimoto's Thyroiditis

Proteobacteria (Pseudomonadota)Actinobacteria (Actinomycetota)Blautia Dorea Bifidobacterium Intestinimonas Turicibacter

Only in Alzheimer's Disease

Helicobacter pylori Escherichia coli Bacteroides fragilis Candida albicans

Taxa depleted

3 shared

Shared

Faecalibacterium prausnitzii Roseburia Lachnospiraceae

Only in Hashimoto's Thyroiditis

Bifidobacterium Lactobacillus Akkermansia muciniphila Coprococcus

Only in Alzheimer's Disease

Saccharomyces Ruminococcus Blautia Eubacterium rectale Bacteroides

Host response elevated

2 shared

Shared

Calprotectin (S100A8/A9)Hepcidin

Only in Hashimoto's Thyroiditis

CeruloplasminAdvanced Glycation End Products

Only in Alzheimer's Disease

Lipocalin-2Proinflammatory CytokinesTransferrin Receptor AlteredFerritin AlteredTREM2

Host response depleted

1 shared

Shared

Butyrate

Only in Hashimoto's Thyroiditis

Selenium Dependent GPxSelenium Dependent TrxRValeric AcidGlutathione PeroxidaseThioredoxin ReductaseSelenium Dependent Selenoproteins

Only in Alzheimer's Disease

Glutathione (GSH)PropionateIndole DerivativesTryptophan MetabolitesSelenoproteinsCeruloplasmin Function

Ecological state

1 shared

Shared

SCFA Depletion

Only in Hashimoto's Thyroiditis

Molecular MimicryIodine Driven DysbiosisTh17 Treg ImbalanceTryptophan Metabolism DisruptionBile Acid DysmetabolismButyrate DepletionOxidative Stress

Only in Alzheimer's Disease

Hypoxia DysbiosisBarrier DysfunctionNeuroinflammationAmyloid SeedingMicroglial ActivationLPS TranslocationBlood Brain Barrier DisruptionAmyloid Cross SeedingLPS EndotoxemiaTMAO ElevationFerroptosisEpigenetic Latency

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Hashimoto's Thyroiditis

Bacterial DeiodinasesLPS EndotoxinIDO1 Kynurenine AhR PathwayThyroid Peroxidase Mimics

Only in Alzheimer's Disease

Curli FibersLipopolysaccharideBacterial AmyloidsSiderophores UreaseMetalloproteasesNickel-UreaseCurli AmyloidLPS