Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

15%: weighted overlap
14: shared signals

First condition

Second condition

Comparison

Graves' DiseaseandAutism Spectrum Disorder

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

22: Graves' Disease references
32: Autism Spectrum Disorder references
0: shared references

Metals elevated or accumulated

3 shared

Shared

Lead Cadmium Mercury

Only in Graves' Disease

Iodine DysregulatedIron

Only in Autism Spectrum Disorder

Copper Nickel Arsenic

Metals depleted or redistributed

3 shared

Shared

Selenium Zinc Iron

Only in Graves' Disease

None indexed

Only in Autism Spectrum Disorder

Glutathione (GSH)

Taxa enriched

1 shared

Taxa depleted

3 shared

Shared

Faecalibacterium prausnitzii Lachnospiraceae Bifidobacterium

Only in Graves' Disease

Akkermansia muciniphila Phascolarctobacterium Roseburia Dialister Butyricimonas Lachnospira

Only in Autism Spectrum Disorder

Coprococcus Lactobacillus

Host response elevated

3 shared

Shared

Hepcidin Transferrin Lipocalin-2

Only in Graves' Disease

None indexed

Only in Autism Spectrum Disorder

Calprotectin (S100A8/A9)Lactoferrin TNF-alpha (Tumor Necrosis Factor Alpha)IL 1IL 6IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)NF KappaBMalondialdehydeFolate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines

Host response depleted

0 shared

Shared

None indexed

Only in Graves' Disease

SelenoproteinsGlutathione PeroxidaseThioredoxin ReductaseDeiodinases

Only in Autism Spectrum Disorder

Glutathione (GSH)SulfateZinc IL-10 (Interleukin-10)TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx ActivityCu Zn SOD

Ecological state

0 shared

Shared

None indexed

Only in Graves' Disease

Intestinal PermeabilityTh17 Treg ImbalanceMolecular Mimicry Estrogen RecirculationSCFA DeficiencyLPS TranslocationBidirectional Gut Thyroid Axis

Only in Autism Spectrum Disorder

Gut Barrier DysfunctionPropionic Acid NeurotoxicityOxidative StressBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalGut Barrier DisruptionMis-MetallationPropionic Acid ElevationSCFA ImbalanceNeuroinflammationDevelopmental Vulnerability

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Graves' Disease

SiderophoresLPSThyroid Peroxidase Mimicry AntigensLPS Endotoxin

Only in Autism Spectrum Disorder

ALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production