Comparative evidence
Compare conditions
Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.
- 21%
- weighted overlap
- 20
- shared signals
Comparison
DepressionandType 2 Diabetes
5 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.
- 38
- Depression references
- 30
- Type 2 Diabetes references
- 5
- shared references
Metals depleted or redistributed
2 sharedTaxa enriched
3 sharedShared
Only in Depression
Only in Type 2 Diabetes
Taxa depleted
3 sharedShared
Only in Depression
Only in Type 2 Diabetes
Host response elevated
3 sharedHost response depleted
3 sharedEcological state
3 sharedShared
Only in Depression
Leaky GutIntestinal PermeabilityLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation
Only in Type 2 Diabetes
LPS ElevationBile Acid DysmetabolismImpaired Intestinal BarrierLipid PeroxidationReduced Microbial DiversityGut Barrier DisruptionBile Acid DysregulationIron Overload Oxidative StressFungal Overgrowth
Virulence and functional enzymes
1 sharedShared
LPS Biosynthesis Enzymes
Only in Depression
TryptophanaseBeta-GlucuronidaseLPS BiosynthesisPro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseBacterial Amyloids Curli
Only in Type 2 Diabetes
LipopolysaccharideCholine TMA LyaseBile Acid DehydrataseCarbohydrate Fermentation EnzymesSiderophoresNickel-UreaseTMA Lyase CutC CutD