Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

23%: weighted overlap
20: shared signals

First condition

Second condition

Comparison

DepressionandPostpartum Depression

7 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

38: Depression references
56: Postpartum Depression references
7: shared references

Metals elevated or accumulated

3 shared

Shared

Cadmium Lead Copper

Only in Depression

Mercury

Only in Postpartum Depression

None indexed

Metals depleted or redistributed

3 shared

Taxa enriched

2 shared

Shared

Escherichia coli Enterobacteriaceae

Only in Depression

Candida albicans Clostridium Bacteroides fragilis Eggerthella Flavonifractor

Only in Postpartum Depression

AlphaproteobacteriaBilophila Desulfovibrio Dialister Enterococcus

Taxa depleted

4 shared

Shared

Faecalibacterium prausnitzii Bifidobacterium Lachnospiraceae Coprococcus

Only in Depression

Prevotella Dialister Lactobacillus

Only in Postpartum Depression

Phascolarctobacterium Veillonella Eubacterium Clostridium Butyricicoccus Holdemanella

Host response elevated

2 shared

Shared

Hepcidin Ceruloplasmin

Only in Depression

Calprotectin (S100A8/A9)Pro Inflammatory CytokinesFerritin

Only in Postpartum Depression

IL 6CRPTNF-alpha (Tumor Necrosis Factor Alpha)IDOCopper

Host response depleted

2 shared

Shared

Zinc Selenium

Only in Depression

Magnesium Iron Glutathione (GSH)Glutathione Peroxidase

Only in Postpartum Depression

Tryptophan GABA (Gamma-Aminobutyric Acid)SCFAFerritin

Ecological state

2 shared

Shared

HPA Axis DysregulationSCFA Depletion

Only in Depression

DysbiosisLeaky GutIntestinal Permeability EndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionTryptophan Shunting IDOHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation

Only in Postpartum Depression

Postpartum Hormonal CrashEstrogen Progesterone WithdrawalIDO Kynurenine ActivationTryptophan DiversionGut Brain Axis DisruptionBile Acid DysmetabolismPrenatal Microbiome SeedingIntergenerational Dysbiosis TransmissionBarrier DysfunctionHormonal DysregulationTryptophan Kynurenine ShuntingIntergenerational Microbiome Transmission

Virulence and functional enzymes

2 shared

Shared

Beta-GlucuronidaseLPS Biosynthesis Enzymes

Only in Depression

TryptophanaseLPS BiosynthesisPro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseBacterial Amyloids Curli

Only in Postpartum Depression

LPS EndotoxinIDO Indoleamine 2 3 DioxygenaseBile Salt Hydrolase (BSH)Sulfite ReductaseSiderophores EnterobactinSiderophores