Comparative evidence
Compare conditions
Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.
- 22%
- weighted overlap
- 20
- shared signals
Comparison
DepressionandParkinson's Disease
6 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.
- 38
- Depression references
- 38
- Parkinson's Disease references
- 6
- shared references
Metals depleted or redistributed
2 sharedShared
Only in Depression
Only in Parkinson's Disease
Taxa enriched
3 sharedShared
Only in Depression
Only in Parkinson's Disease
Taxa depleted
4 sharedShared
Only in Depression
Only in Parkinson's Disease
Host response elevated
3 sharedHost response depleted
1 sharedShared
Only in Depression
Only in Parkinson's Disease
Ecological state
2 sharedShared
SCFA DepletionBlood Brain Barrier Disruption
Only in Depression
DysbiosisLeaky GutIntestinal PermeabilityEndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOHPA Axis HyperactivationNeuroinflammation
Only in Parkinson's Disease
HypoxiaIron Rich MicroenvironmentFunctional ShieldingBacterial TranslocationGut PermeabilityDysbiotic FermentationAcidic MicroenvironmentFerroptosisAlpha Synuclein Gut SeedingLPS EndotoxemiaVagal Nerve PropagationHypoxia GutSiderophore Competition
Virulence and functional enzymes
1 sharedShared
Bacterial Amyloids Curli
Only in Depression
TryptophanaseBeta-GlucuronidaseLPS BiosynthesisPro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis Enzymes
Only in Parkinson's Disease
Iron SiderophoresZinc-MetalloproteaseNickel-UreaseNickel HydrogenaseMucinaseLipopolysaccharide LPSNiFe-HydrogenaseCurli AmyloidLPSSiderophores