Comparative evidence
Compare conditions
Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.
- 19%
- weighted overlap
- 16
- shared signals
Comparison
DepressionandObesity
2 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.
- 38
- Depression references
- 31
- Obesity references
- 2
- shared references
Metals depleted or redistributed
1 sharedTaxa enriched
3 sharedShared
Only in Depression
Only in Obesity
Taxa depleted
3 sharedShared
Only in Depression
Only in Obesity
Host response elevated
3 sharedHost response depleted
1 sharedShared
Only in Depression
Only in Obesity
Ecological state
1 sharedShared
Only in Depression
DysbiosisLeaky GutIntestinal PermeabilityLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOSCFA DepletionHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation
Only in Obesity
HypoxiaMetal Driven DysbiosisReduced SCFA ProductionIncreased LPSIntestinal Permeability IncreaseFermentative MetabolismAcidic MicroenvironmentMetabolic EndotoxemiaReduced Microbial DiversityIncreased Energy HarvestBile Acid DysregulationVirome Depletion
Virulence and functional enzymes
2 sharedShared
Beta-GlucuronidaseLPS Biosynthesis
Only in Depression
TryptophanasePro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli