Comparative evidence
Compare conditions
Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.
- 9%
- weighted overlap
- 9
- shared signals
Comparison
DepressionandNecrotizing Enterocolitis
0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.
- 38
- Depression references
- 19
- Necrotizing Enterocolitis references
- 0
- shared references
Metals depleted or redistributed
1 sharedTaxa enriched
1 sharedShared
Only in Depression
Only in Necrotizing Enterocolitis
KlebsiellaClostridium perfringensStaphylococcusKlebsiella pneumoniaeClostridium Perfringens (Toxigenic)Sphingomonas Spp.Clostridium Spp. (Obligate Anaerobe Cluster)Bacteroides/Prevotella (Obligate Anaerobe Cluster)Staphylococcus epidermidisEnterococcus
Taxa depleted
2 sharedHost response elevated
2 sharedShared
Calprotectin (S100A8/A9)Pro Inflammatory Cytokines
Only in Depression
Only in Necrotizing Enterocolitis
Lactoferrin EndogenousTLR4 ExpressionLPSTNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)IL 6
Host response depleted
1 sharedEcological state
0 sharedShared
None indexed
Only in Depression
DysbiosisLeaky GutIntestinal PermeabilityEndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOSCFA DepletionHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation
Only in Necrotizing Enterocolitis
Proteobacteria Bloom 2 Weeks Pre DiagnosisVirome Convergence 10 Days Pre OnsetTLR4 Upregulation In Premature EpitheliumBifidobacterium Absence As PreconditionHMO Mediated Colonization ResistanceFeed Forward Barrier DestructionProteobacteria BloomTLR4 Feed Forward LoopVirome ConvergenceImmature BarrierParenteral Iron OverloadBiofilmBile Acid Accumulation ASBT UpregulationMuc2 Depletion Mucosal Barrier FailureObligate Anaerobe Mucosal InvasionGut Brain Axis NDI RiskAntibiotic Driven Richness Nadir Week4
Virulence and functional enzymes
2 sharedShared
LPS BiosynthesisBiofilm Formation Enzymes
Only in Depression
TryptophanaseBeta-GlucuronidasePro Inflammatory Metabolite SynthesisIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli