Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

16%: weighted overlap
16: shared signals

First condition

Second condition

Comparison

DepressionandLong COVID

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

38: Depression references
18: Long COVID references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Depression

Cadmium Lead Mercury Copper

Only in Long COVID

Zinc Arsenic Thallium

Metals depleted or redistributed

2 shared

Taxa enriched

3 shared

Shared

Candida albicans Escherichia coli Enterobacteriaceae

Only in Depression

Clostridium Bacteroides fragilis Eggerthella Flavonifractor

Only in Long COVID

Streptococcus Enterococcus Veillonella Fusobacterium nucleatum Aspergillus Klebsiella pneumoniae

Taxa depleted

4 shared

Shared

Faecalibacterium prausnitzii Bifidobacterium Lachnospiraceae Lactobacillus

Only in Depression

Prevotella Coprococcus Dialister

Only in Long COVID

Roseburia Akkermansia muciniphila

Host response elevated

2 shared

Shared

Hepcidin Calprotectin (S100A8/A9)

Only in Depression

Pro Inflammatory CytokinesCeruloplasmin Ferritin

Only in Long COVID

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)IFN-gamma (Interferon Gamma)LPS In CirculationPD 1 On CD8TIM 3 On CD8AutoantibodiesZinc In Secretions

Host response depleted

2 shared

Shared

Selenium Glutathione (GSH)

Only in Depression

Zinc Magnesium IronGlutathione Peroxidase

Only in Long COVID

Regulatory T CellsNK Cell FunctionMemory B CellsSIgAButyrateIron In Tissues

Ecological state

1 shared

Shared

SCFA Depletion

Only in Depression

DysbiosisLeaky GutIntestinal Permeability EndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation

Only in Long COVID

Self Perpetuating Dysbiosis LoopAnaerobe To Aerobe ShiftSCFA CollapseBacterial Translocation EndotoxemiaGut Lung Axis DisruptionGut Brain Axis DisruptionTryptophan AhR DysmetabolismVirome Co DysbiosisMulti Kingdom DysbiosisNon Linear Recovery TrajectoryStrain Level Diversity CollapseEstrobolome DysfunctionUremic Metabolite AccumulationHypoxia CellularAerobe BloomBarrier DysfunctionBacterial TranslocationMulti Kingdom Co DysbiosisNon Linear Recovery

Virulence and functional enzymes

2 shared

Shared

Beta-GlucuronidaseLPS Biosynthesis Enzymes

Only in Depression

TryptophanaseLPS BiosynthesisPro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseBacterial Amyloids Curli

Only in Long COVID

LPS Synthesis TransportSiderophoresAdhesion Invasion FactorsBile Salt Hydrolase (BSH)Polysaccharide DegradationBeta Lactamases