Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

15%: weighted overlap
14: shared signals

First condition

Second condition

Comparison

Autism Spectrum DisorderandGraves' Disease

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

32: Autism Spectrum Disorder references
22: Graves' Disease references
0: shared references

Metals elevated or accumulated

3 shared

Shared

Lead Mercury Cadmium

Only in Autism Spectrum Disorder

Copper Nickel Arsenic

Only in Graves' Disease

Iodine DysregulatedIron

Metals depleted or redistributed

3 shared

Shared

Zinc Iron Selenium

Only in Autism Spectrum Disorder

Glutathione (GSH)

Only in Graves' Disease

None indexed

Taxa enriched

1 shared

Taxa depleted

3 shared

Shared

Bifidobacterium Faecalibacterium prausnitzii Lachnospiraceae

Only in Autism Spectrum Disorder

Coprococcus Lactobacillus

Only in Graves' Disease

Akkermansia muciniphila Phascolarctobacterium Roseburia Dialister Butyricimonas Lachnospira

Host response elevated

3 shared

Shared

Transferrin Hepcidin Lipocalin-2

Only in Autism Spectrum Disorder

Calprotectin (S100A8/A9)Lactoferrin TNF-alpha (Tumor Necrosis Factor Alpha)IL 1IL 6IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)NF KappaBMalondialdehydeFolate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines

Only in Graves' Disease

None indexed

Host response depleted

0 shared

Shared

None indexed

Only in Autism Spectrum Disorder

Glutathione (GSH)SulfateZinc IL-10 (Interleukin-10)TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx ActivityCu Zn SOD

Only in Graves' Disease

SelenoproteinsGlutathione PeroxidaseThioredoxin ReductaseDeiodinases

Ecological state

0 shared

Shared

None indexed

Only in Autism Spectrum Disorder

Gut Barrier DysfunctionPropionic Acid NeurotoxicityOxidative StressBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalGut Barrier DisruptionMis-MetallationPropionic Acid ElevationSCFA ImbalanceNeuroinflammationDevelopmental Vulnerability

Only in Graves' Disease

Intestinal PermeabilityTh17 Treg ImbalanceMolecular Mimicry Estrogen RecirculationSCFA DeficiencyLPS TranslocationBidirectional Gut Thyroid Axis

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Autism Spectrum Disorder

ALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production

Only in Graves' Disease

SiderophoresLPSThyroid Peroxidase Mimicry AntigensLPS Endotoxin