Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

37%: weighted overlap
35: shared signals

First condition

Second condition

Comparison

Alzheimer's DiseaseandParkinson's Disease

11 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

31: Alzheimer's Disease references
38: Parkinson's Disease references
11: shared references

Metals elevated or accumulated

7 shared

Shared

Lead Cadmium Manganese Iron Copper Mercury Nickel

Only in Alzheimer's Disease

Arsenic AluminumZinc In Plaques

Only in Parkinson's Disease

Iron Substantia NigraManganese Basal Ganglia

Metals depleted or redistributed

5 shared

Shared

Zinc SeleniumCopper BrainZinc SerumGlutathione (GSH)

Only in Alzheimer's Disease

Copper

Only in Parkinson's Disease

None indexed

Taxa enriched

4 shared

Taxa depleted

4 shared

Shared

Lachnospiraceae Roseburia Blautia Faecalibacterium prausnitzii

Only in Alzheimer's Disease

Saccharomyces Ruminococcus Eubacterium rectale Bacteroides

Only in Parkinson's Disease

PrevotellaLactic Acid BacteriaCoprococcus

Host response elevated

4 shared

Shared

Hepcidin Lipocalin-2 Calprotectin (S100A8/A9)Transferrin Receptor Altered

Only in Alzheimer's Disease

Proinflammatory CytokinesFerritin AlteredTREM2

Only in Parkinson's Disease

TransferrinInflammatory Cytokines TNF IL6 IL1betaFerritin

Host response depleted

2 shared

Shared

Glutathione (GSH)Selenoproteins

Only in Alzheimer's Disease

ButyratePropionateIndole DerivativesTryptophan MetabolitesCeruloplasmin Function

Only in Parkinson's Disease

Lactoferrin Short-Chain Fatty Acids (SCFAs)GPX4Neuromelanin Iron Binding Capacity

Ecological state

5 shared

Shared

HypoxiaBlood Brain Barrier DisruptionLPS EndotoxemiaSCFA DepletionFerroptosis

Only in Alzheimer's Disease

DysbiosisBarrier DysfunctionNeuroinflammationAmyloid SeedingMicroglial ActivationLPS TranslocationAmyloid Cross SeedingTMAO ElevationEpigenetic Latency

Only in Parkinson's Disease

Iron Rich MicroenvironmentFunctional ShieldingBacterial TranslocationGut PermeabilityDysbiotic FermentationAcidic MicroenvironmentAlpha Synuclein Gut SeedingVagal Nerve PropagationHypoxia GutSiderophore Competition

Virulence and functional enzymes

4 shared

Shared

Siderophores Nickel-UreaseCurli AmyloidLPS

Only in Alzheimer's Disease

Curli FibersLipopolysaccharideBacterial AmyloidsUreaseMetalloproteasesBeta-Glucuronidase

Only in Parkinson's Disease

Iron SiderophoresZinc-MetalloproteaseNickel HydrogenaseMucinaseLipopolysaccharide LPSBacterial Amyloids CurliNiFe-Hydrogenase