Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

19%: weighted overlap
18: shared signals

First condition

Second condition

Comparison

Alzheimer's DiseaseandHashimoto's Thyroiditis

1 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

31: Alzheimer's Disease references
17: Hashimoto's Thyroiditis references
1: shared references

Metals elevated or accumulated

5 shared

Shared

Lead Cadmium Copper Mercury Nickel

Only in Alzheimer's Disease

Arsenic Manganese Iron AluminumZinc In Plaques

Only in Hashimoto's Thyroiditis

Iodine Excess

Metals depleted or redistributed

2 shared

Taxa enriched

3 shared

Shared

Klebsiella pneumoniae Prevotella Akkermansia muciniphila

Only in Alzheimer's Disease

Helicobacter pylori Escherichia coli Bacteroides fragilis Candida albicans

Only in Hashimoto's Thyroiditis

Proteobacteria (Pseudomonadota)Actinobacteria (Actinomycetota)Blautia Dorea Bifidobacterium Intestinimonas Turicibacter

Taxa depleted

3 shared

Shared

Lachnospiraceae Roseburia Faecalibacterium prausnitzii

Only in Alzheimer's Disease

Saccharomyces Ruminococcus Blautia Eubacterium rectale Bacteroides

Only in Hashimoto's Thyroiditis

Bifidobacterium Lactobacillus Akkermansia muciniphila Coprococcus

Host response elevated

2 shared

Shared

Hepcidin Calprotectin (S100A8/A9)

Only in Alzheimer's Disease

Lipocalin-2Proinflammatory CytokinesTransferrin Receptor AlteredFerritin AlteredTREM2

Only in Hashimoto's Thyroiditis

CeruloplasminAdvanced Glycation End Products

Host response depleted

1 shared

Shared

Butyrate

Only in Alzheimer's Disease

Glutathione (GSH)PropionateIndole DerivativesTryptophan MetabolitesSelenoproteinsCeruloplasmin Function

Only in Hashimoto's Thyroiditis

Selenium Dependent GPxSelenium Dependent TrxRValeric AcidGlutathione PeroxidaseThioredoxin ReductaseSelenium Dependent Selenoproteins

Ecological state

1 shared

Shared

SCFA Depletion

Only in Alzheimer's Disease

Hypoxia DysbiosisBarrier DysfunctionNeuroinflammationAmyloid SeedingMicroglial ActivationLPS TranslocationBlood Brain Barrier DisruptionAmyloid Cross SeedingLPS EndotoxemiaTMAO ElevationFerroptosisEpigenetic Latency

Only in Hashimoto's Thyroiditis

Molecular MimicryIodine Driven DysbiosisTh17 Treg ImbalanceTryptophan Metabolism DisruptionBile Acid DysmetabolismButyrate DepletionOxidative Stress

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Alzheimer's Disease

Curli FibersLipopolysaccharideBacterial AmyloidsSiderophores UreaseMetalloproteasesNickel-UreaseCurli AmyloidLPS

Only in Hashimoto's Thyroiditis

Bacterial DeiodinasesLPS EndotoxinIDO1 Kynurenine AhR PathwayThyroid Peroxidase Mimics