Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

17%: weighted overlap
15: shared signals

First condition

Second condition

Comparison

Type 2 DiabetesandHashimoto's Thyroiditis

1 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

30: Type 2 Diabetes references
17: Hashimoto's Thyroiditis references
1: shared references

Metals elevated or accumulated

3 shared

Shared

Nickel Cadmium Lead

Only in Type 2 Diabetes

Iron Arsenic

Only in Hashimoto's Thyroiditis

Iodine ExcessMercury Copper

Metals depleted or redistributed

1 shared

Taxa enriched

1 shared

Shared

Prevotella

Only in Type 2 Diabetes

Escherichia coli Enterobacteriaceae Streptococcus Enterococcus Candida albicans Helicobacter pylori Campylobacter jejuni

Only in Hashimoto's Thyroiditis

Proteobacteria (Pseudomonadota)Actinobacteria (Actinomycetota)Blautia Dorea Akkermansia muciniphila Bifidobacterium Intestinimonas Turicibacter Klebsiella pneumoniae

Taxa depleted

5 shared

Shared

Faecalibacterium prausnitzii Bifidobacterium Akkermansia muciniphila Lachnospiraceae Roseburia

Only in Type 2 Diabetes

Ruminococcus Bacteroides fragilis Blautia

Only in Hashimoto's Thyroiditis

Lactobacillus Coprococcus

Host response elevated

2 shared

Shared

Hepcidin Ceruloplasmin

Only in Type 2 Diabetes

LipopolysaccharideInflammatory CytokinesTNF-alpha (Tumor Necrosis Factor Alpha)IL 6Ferritin

Only in Hashimoto's Thyroiditis

Calprotectin (S100A8/A9)Advanced Glycation End Products

Host response depleted

1 shared

Shared

Butyrate

Only in Type 2 Diabetes

PropionateAcetateBile AcidsGlutathione (GSH)Zinc Chromium Manganese Magnesium

Only in Hashimoto's Thyroiditis

Selenium Dependent GPxSelenium Dependent TrxRValeric AcidGlutathione PeroxidaseThioredoxin ReductaseSelenium Dependent Selenoproteins

Ecological state

2 shared

Shared

SCFA DepletionBile Acid Dysmetabolism

Only in Type 2 Diabetes

DysbiosisLPS ElevationImpaired Intestinal BarrierLipid PeroxidationReduced Microbial DiversityEndotoxemiaGut Barrier DisruptionBile Acid DysregulationIron Overload Oxidative StressFungal Overgrowth

Only in Hashimoto's Thyroiditis

Molecular MimicryIodine Driven DysbiosisTh17 Treg ImbalanceTryptophan Metabolism DisruptionButyrate DepletionOxidative Stress

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Type 2 Diabetes

LipopolysaccharideCholine TMA LyaseBile Acid DehydrataseCarbohydrate Fermentation EnzymesSiderophoresLPS Biosynthesis EnzymesNickel-UreaseTMA Lyase CutC CutD

Only in Hashimoto's Thyroiditis

Bacterial DeiodinasesBeta-GlucuronidaseLPS EndotoxinIDO1 Kynurenine AhR PathwayThyroid Peroxidase Mimics