Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

19%: weighted overlap
18: shared signals

First condition

Second condition

Comparison

Type 1 DiabetesandDepression

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

20: Type 1 Diabetes references
38: Depression references
0: shared references

Metals elevated or accumulated

3 shared

Metals depleted or redistributed

2 shared

Shared

Zinc Selenium

Only in Type 1 Diabetes

Glutathione (GSH)

Only in Depression

Magnesium Iron

Taxa enriched

2 shared

Shared

Escherichia coli Enterobacteriaceae

Only in Type 1 Diabetes

Bacteroides Ruminococcus gnavus Streptococcus Veillonella Sutterella Akkermansia muciniphila Prevotellaceae

Only in Depression

Candida albicans Clostridium Bacteroides fragilis Eggerthella Flavonifractor

Taxa depleted

5 shared

Shared

Faecalibacterium prausnitzii Bifidobacterium Prevotella Lactobacillus Lachnospiraceae

Only in Type 1 Diabetes

Roseburia Subdoligranulum Eubacterium rectaleClostridium Clusters IV/XIVaBlautia Eubacterium eligens Clostridium

Only in Depression

Coprococcus Dialister

Host response elevated

2 shared

Shared

Hepcidin Ferritin

Only in Type 1 Diabetes

ZnT8 AutoantibodiesGADAIA 2AInsulin AutoantibodiesType 1 IFN SignatureTLR4 NF KB ActivationAnti ZnT8 Autoantibodies

Only in Depression

Calprotectin (S100A8/A9)Pro Inflammatory CytokinesCeruloplasmin

Host response depleted

2 shared

Shared

Glutathione (GSH)Zinc

Only in Type 1 Diabetes

Treg FunctionGPR43 SCFA SignalingZinc BioavailabilityMetallothionein

Only in Depression

Magnesium Iron SeleniumGlutathione Peroxidase

Ecological state

0 shared

Shared

None indexed

Only in Type 1 Diabetes

Butyrate SCFA Ratio ShiftLeaky Gut Precedes OnsetBacterial Translocation To PLNMucin Layer ThinningImmunoinhibitory LPSCVB4 Microbiome SynergyTwo Step Temporal ModelMicrobiome Changes Precede AutoantibodiesBacteroidetes Firmicutes Ratio InversionGut Barrier CompromiseLPS Translocation To PLNSCFA GPR43 Axis DisruptionTreg DepletionViral Dysbiosis TriggerDevelopmental Vulnerability Window

Only in Depression

DysbiosisLeaky GutIntestinal Permeability EndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOSCFA DepletionHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation

Virulence and functional enzymes

2 shared

Shared

LPS BiosynthesisBeta-Glucuronidase

Only in Type 1 Diabetes

LPS Biosynthesis GenesIron Acquisition FecB IsdDEFType VI Secretion SystemsDNA Adenine Methyltransferases

Only in Depression

TryptophanasePro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli