Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

14%: weighted overlap
12: shared signals

First condition

Second condition

Comparison

Rheumatoid ArthritisandAlzheimer's Disease

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

7: Rheumatoid Arthritis references
31: Alzheimer's Disease references
0: shared references

Metals elevated or accumulated

4 shared

Metals depleted or redistributed

0 shared

Shared

None indexed

Only in Rheumatoid Arthritis

Vitamin D Nickel

Only in Alzheimer's Disease

Copper Zinc SeleniumCopper BrainZinc SerumGlutathione (GSH)

Taxa enriched

1 shared

Shared

Escherichia coli

Only in Rheumatoid Arthritis

Prevotella copri Enterobacteriaceae Collinsella

Only in Alzheimer's Disease

Helicobacter pylori Klebsiella pneumoniae Bacteroides fragilis Prevotella Akkermansia muciniphila Candida albicans

Taxa depleted

2 shared

Shared

Faecalibacterium prausnitzii Lachnospiraceae

Only in Rheumatoid Arthritis

Bifidobacterium Bacteroides fragilis

Only in Alzheimer's Disease

Saccharomyces Ruminococcus Roseburia Blautia Eubacterium rectale Bacteroides

Host response elevated

2 shared

Shared

Hepcidin Calprotectin (S100A8/A9)

Only in Rheumatoid Arthritis

Ceruloplasmin

Only in Alzheimer's Disease

Lipocalin-2Proinflammatory CytokinesTransferrin Receptor AlteredFerritin AlteredTREM2

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Rheumatoid Arthritis

Vitamin D

Only in Alzheimer's Disease

ButyratePropionateIndole DerivativesTryptophan MetabolitesSelenoproteinsCeruloplasmin Function

Ecological state

1 shared

Shared

Barrier Dysfunction

Only in Rheumatoid Arthritis

Mucosal Origin AutoimmunityMolecular MimicryTh17 DominanceMetal VitD Bone AxisSoil Food Chain Exposure

Only in Alzheimer's Disease

Hypoxia Dysbiosis NeuroinflammationAmyloid SeedingMicroglial ActivationLPS TranslocationBlood Brain Barrier DisruptionAmyloid Cross SeedingLPS EndotoxemiaSCFA DepletionTMAO ElevationFerroptosisEpigenetic Latency

Virulence and functional enzymes

1 shared

Shared

Siderophores

Only in Rheumatoid Arthritis

MetalloproteinasesLPS Biosynthesis Enzymes

Only in Alzheimer's Disease

Curli FibersLipopolysaccharideBacterial AmyloidsUreaseMetalloproteasesNickel-UreaseCurli AmyloidLPSBeta-Glucuronidase