Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

16%: weighted overlap
15: shared signals

First condition

Second condition

Comparison

Polycystic Ovary SyndromeandDepression

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

25: Polycystic Ovary Syndrome references
38: Depression references
0: shared references

Metals elevated or accumulated

4 shared

Shared

Copper Cadmium Lead Mercury

Only in Polycystic Ovary Syndrome

Antimony Iron Nickel Zinc Manganese Arsenic

Only in Depression

None indexed

Metals depleted or redistributed

1 shared

Taxa enriched

1 shared

Shared

Escherichia coli

Only in Polycystic Ovary Syndrome

Prevotella Bacteroides vulgatus Phocaeicola Mediterraneibacter Oscillospiraceae Mortierella Alistipes

Only in Depression

Candida albicans Clostridium Bacteroides fragilis Eggerthella Enterobacteriaceae Flavonifractor

Taxa depleted

3 shared

Shared

Lactobacillus Bifidobacterium Faecalibacterium prausnitzii

Only in Polycystic Ovary Syndrome

Alistipes Akkermansia muciniphila

Only in Depression

Lachnospiraceae Prevotella Coprococcus Dialister

Host response elevated

1 shared

Shared

Ceruloplasmin

Only in Polycystic Ovary Syndrome

Hs CRPTNF-alpha (Tumor Necrosis Factor Alpha)Inflammatory CytokinesOxidative Stress Markers TOS MDA

Only in Depression

Hepcidin Calprotectin (S100A8/A9)Pro Inflammatory CytokinesFerritin

Host response depleted

2 shared

Shared

Glutathione (GSH)Magnesium

Only in Polycystic Ovary Syndrome

Total Antioxidant Capacity TACSuperoxide Dismutase SODSuperoxide DismutaseTotal Antioxidant Status

Only in Depression

Zinc Iron SeleniumGlutathione Peroxidase

Ecological state

2 shared

Shared

DysbiosisSCFA Depletion

Only in Polycystic Ovary Syndrome

Reduced Microbial DiversityEstrogen RecirculationLow Dietary FiberFermentative DysbiosisAndrogen Mediated DysbiosisObesity Amplified DysbiosisHyperandrogenism Driven DysbiosisInsulin Resistance Dysbiosis LoopMetalloestrogen BurdenAntioxidant CollapseEstrobolome DysregulationMycobiome Disruption

Only in Depression

Leaky GutIntestinal Permeability EndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Polycystic Ovary Syndrome

Siderophores Iron AcquisitionLipopolysaccharide ProductionCopper Dependent OxidasesUrease

Only in Depression

TryptophanaseLPS BiosynthesisPro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli