Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

14%: weighted overlap
16: shared signals

First condition

Second condition

Comparison

Parkinson's DiseaseandAutism Spectrum Disorder

3 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

38: Parkinson's Disease references
32: Autism Spectrum Disorder references
3: shared references

Metals elevated or accumulated

5 shared

Shared

Lead Nickel Copper Cadmium Mercury

Only in Parkinson's Disease

Iron ManganeseIron Substantia NigraManganese Basal Ganglia

Only in Autism Spectrum Disorder

Arsenic

Metals depleted or redistributed

3 shared

Shared

Glutathione (GSH)Zinc Selenium

Only in Parkinson's Disease

Copper BrainZinc Serum

Only in Autism Spectrum Disorder

Iron

Taxa enriched

0 shared

Shared

None indexed

Only in Parkinson's Disease

Enterobacteriaceae Akkermansia muciniphila Candida albicans Escherichia coli Porphyromonas Lactobacillus Helicobacter pylori

Only in Autism Spectrum Disorder

Bacteroides Parabacteroides ClostridiumEubacterium CoprostanoligenesDesulfovibrio

Taxa depleted

3 shared

Host response elevated

4 shared

Shared

Hepcidin Calprotectin (S100A8/A9)Transferrin Lipocalin-2

Only in Parkinson's Disease

Inflammatory Cytokines TNF IL6 IL1betaFerritinTransferrin Receptor Altered

Only in Autism Spectrum Disorder

Lactoferrin TNF-alpha (Tumor Necrosis Factor Alpha)IL 1IL 6IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)NF KappaBMalondialdehydeFolate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Parkinson's Disease

Lactoferrin Short-Chain Fatty Acids (SCFAs)GPX4SelenoproteinsNeuromelanin Iron Binding Capacity

Only in Autism Spectrum Disorder

SulfateZinc IL-10 (Interleukin-10)TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx ActivityCu Zn SOD

Ecological state

0 shared

Shared

None indexed

Only in Parkinson's Disease

HypoxiaIron Rich MicroenvironmentFunctional ShieldingBacterial TranslocationGut PermeabilityDysbiotic FermentationAcidic Microenvironment FerroptosisAlpha Synuclein Gut SeedingBlood Brain Barrier DisruptionLPS EndotoxemiaSCFA DepletionVagal Nerve PropagationHypoxia GutSiderophore Competition

Only in Autism Spectrum Disorder

Gut Barrier DysfunctionPropionic Acid NeurotoxicityOxidative StressBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalGut Barrier DisruptionMis-MetallationPropionic Acid ElevationSCFA ImbalanceNeuroinflammationDevelopmental Vulnerability

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Parkinson's Disease

Iron SiderophoresZinc-Metalloprotease Nickel-UreaseNickel HydrogenaseMucinaseLipopolysaccharide LPSBacterial Amyloids CurliNiFe-HydrogenaseCurli AmyloidLPSSiderophores

Only in Autism Spectrum Disorder

Beta-GlucuronidaseALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production