Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

14%: weighted overlap
12: shared signals

First condition

Second condition

Comparison

ObesityandHashimoto's Thyroiditis

1 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

31: Obesity references
17: Hashimoto's Thyroiditis references
1: shared references

Metals elevated or accumulated

3 shared

Shared

Cadmium Nickel Lead

Only in Obesity

Manganese Zinc Iron

Only in Hashimoto's Thyroiditis

Iodine ExcessMercury Copper

Metals depleted or redistributed

0 shared

Shared

None indexed

Only in Obesity

Glutathione (GSH)Magnesium Barium Vanadium Titanium

Only in Hashimoto's Thyroiditis

Selenium Iron Zinc

Taxa enriched

0 shared

Shared

None indexed

Only in Obesity

Escherichia coli Streptococcus Enterobacteriaceae Fusobacterium Bacteroides fragilis

Only in Hashimoto's Thyroiditis

Proteobacteria (Pseudomonadota)Actinobacteria (Actinomycetota)Blautia Dorea Prevotella Akkermansia muciniphila Bifidobacterium Intestinimonas Turicibacter Klebsiella pneumoniae

Taxa depleted

5 shared

Host response elevated

2 shared

Shared

Hepcidin Calprotectin (S100A8/A9)

Only in Obesity

Transferrin Lipocalin-2 Lactoferrin Ferritin

Only in Hashimoto's Thyroiditis

CeruloplasminAdvanced Glycation End Products

Host response depleted

1 shared

Shared

Butyrate

Only in Obesity

Glutathione (GSH)Short-Chain Fatty Acids (SCFAs)

Only in Hashimoto's Thyroiditis

Selenium Dependent GPxSelenium Dependent TrxRValeric AcidGlutathione PeroxidaseThioredoxin ReductaseSelenium Dependent Selenoproteins

Ecological state

0 shared

Shared

None indexed

Only in Obesity

HypoxiaMetal Driven DysbiosisReduced SCFA ProductionIncreased LPSEndotoxemiaIntestinal Permeability IncreaseFermentative Metabolism Acidic MicroenvironmentMetabolic EndotoxemiaReduced Microbial DiversityIncreased Energy HarvestBile Acid DysregulationVirome Depletion

Only in Hashimoto's Thyroiditis

Molecular MimicryIodine Driven DysbiosisTh17 Treg ImbalanceSCFA DepletionTryptophan Metabolism DisruptionBile Acid DysmetabolismButyrate DepletionOxidative Stress

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Obesity

TMA LyaseSiderophores Nickel-UreaseNickel HydrogenaseZinc MetalloproteasesLPS Biosynthesis

Only in Hashimoto's Thyroiditis

Bacterial DeiodinasesLPS EndotoxinIDO1 Kynurenine AhR PathwayThyroid Peroxidase Mimics