Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

6%: weighted overlap
5: shared signals

First condition

Second condition

Comparison

Necrotizing EnterocolitisandHashimoto's Thyroiditis

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

19: Necrotizing Enterocolitis references
17: Hashimoto's Thyroiditis references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Necrotizing Enterocolitis

Iron

Only in Hashimoto's Thyroiditis

Iodine ExcessCadmium Lead Mercury Nickel Copper

Metals depleted or redistributed

1 shared

Shared

Zinc

Only in Necrotizing Enterocolitis

None indexed

Only in Hashimoto's Thyroiditis

Selenium Iron

Taxa enriched

1 shared

Shared

Klebsiella pneumoniae

Only in Necrotizing Enterocolitis

Klebsiella Escherichia coli Clostridium perfringens StaphylococcusClostridium Perfringens (Toxigenic)Sphingomonas Spp.Clostridium Spp. (Obligate Anaerobe Cluster)Bacteroides/Prevotella (Obligate Anaerobe Cluster)Staphylococcus epidermidis Enterococcus

Only in Hashimoto's Thyroiditis

Proteobacteria (Pseudomonadota)Actinobacteria (Actinomycetota)Blautia Dorea Prevotella Akkermansia muciniphila Bifidobacterium Intestinimonas Turicibacter

Taxa depleted

2 shared

Shared

Bifidobacterium Lactobacillus

Only in Necrotizing Enterocolitis

BacteroidesBacteroidetes (Phylum)

Only in Hashimoto's Thyroiditis

Faecalibacterium prausnitzii Akkermansia muciniphila Roseburia Lachnospiraceae Coprococcus

Host response elevated

1 shared

Shared

Calprotectin (S100A8/A9)

Only in Necrotizing Enterocolitis

Lactoferrin EndogenousPro Inflammatory CytokinesTLR4 ExpressionLPSTNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)IL 6

Only in Hashimoto's Thyroiditis

Hepcidin CeruloplasminAdvanced Glycation End Products

Host response depleted

0 shared

Shared

None indexed

Only in Necrotizing Enterocolitis

Zinc Defensins AcetateLactateSecretory IgA

Only in Hashimoto's Thyroiditis

Selenium Dependent GPxSelenium Dependent TrxRButyrateValeric AcidGlutathione PeroxidaseThioredoxin ReductaseSelenium Dependent Selenoproteins

Ecological state

0 shared

Shared

None indexed

Only in Necrotizing Enterocolitis

Proteobacteria Bloom 2 Weeks Pre DiagnosisVirome Convergence 10 Days Pre OnsetTLR4 Upregulation In Premature EpitheliumBifidobacterium Absence As PreconditionHMO Mediated Colonization ResistanceFeed Forward Barrier DestructionProteobacteria BloomTLR4 Feed Forward LoopVirome ConvergenceImmature BarrierParenteral Iron OverloadBiofilmBile Acid Accumulation ASBT UpregulationMuc2 Depletion Mucosal Barrier FailureObligate Anaerobe Mucosal InvasionGut Brain Axis NDI RiskAntibiotic Driven Richness Nadir Week4

Only in Hashimoto's Thyroiditis

Molecular MimicryIodine Driven DysbiosisTh17 Treg ImbalanceSCFA DepletionTryptophan Metabolism DisruptionBile Acid DysmetabolismButyrate DepletionOxidative Stress

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Necrotizing Enterocolitis

SiderophoresLPS BiosynthesisAlpha ToxinPerfringolysin OBiofilm Formation Enzymes

Only in Hashimoto's Thyroiditis

Bacterial DeiodinasesBeta-GlucuronidaseLPS EndotoxinIDO1 Kynurenine AhR PathwayThyroid Peroxidase Mimics