Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

10%: weighted overlap
10: shared signals

First condition

Second condition

Comparison

Long COVIDandNecrotizing Enterocolitis

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

18: Long COVID references
19: Necrotizing Enterocolitis references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Long COVID

Zinc Arsenic Thallium

Only in Necrotizing Enterocolitis

Iron

Metals depleted or redistributed

0 shared

Shared

None indexed

Only in Long COVID

Iron Selenium Copper Nickel Glutathione (GSH)

Only in Necrotizing Enterocolitis

Zinc

Taxa enriched

3 shared

Shared

Enterococcus Escherichia coli Klebsiella pneumoniae

Only in Long COVID

Enterobacteriaceae Streptococcus Veillonella Candida albicans Fusobacterium nucleatum Aspergillus

Only in Necrotizing Enterocolitis

Klebsiella Clostridium perfringens StaphylococcusClostridium Perfringens (Toxigenic)Sphingomonas Spp.Clostridium Spp. (Obligate Anaerobe Cluster)Bacteroides/Prevotella (Obligate Anaerobe Cluster)Staphylococcus epidermidis

Taxa depleted

2 shared

Shared

Bifidobacterium Lactobacillus

Only in Long COVID

Faecalibacterium prausnitzii Roseburia Akkermansia muciniphila Lachnospiraceae

Only in Necrotizing Enterocolitis

BacteroidesBacteroidetes (Phylum)

Host response elevated

4 shared

Shared

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)Calprotectin (S100A8/A9)

Only in Long COVID

IFN-gamma (Interferon Gamma)LPS In CirculationPD 1 On CD8TIM 3 On CD8AutoantibodiesHepcidinZinc In Secretions

Only in Necrotizing Enterocolitis

Lactoferrin EndogenousPro Inflammatory CytokinesTLR4 ExpressionLPS

Host response depleted

0 shared

Shared

None indexed

Only in Long COVID

Regulatory T CellsNK Cell FunctionMemory B CellsSIgAGlutathione (GSH)Butyrate SeleniumIron In Tissues

Only in Necrotizing Enterocolitis

Zinc Defensins AcetateLactateSecretory IgA

Ecological state

0 shared

Shared

None indexed

Only in Long COVID

Self Perpetuating Dysbiosis LoopAnaerobe To Aerobe ShiftSCFA CollapseBacterial Translocation EndotoxemiaGut Lung Axis DisruptionGut Brain Axis DisruptionTryptophan AhR DysmetabolismVirome Co DysbiosisMulti Kingdom DysbiosisNon Linear Recovery TrajectoryStrain Level Diversity CollapseEstrobolome DysfunctionUremic Metabolite AccumulationHypoxia CellularAerobe BloomBarrier DysfunctionBacterial TranslocationMulti Kingdom Co DysbiosisSCFA DepletionNon Linear Recovery

Only in Necrotizing Enterocolitis

Proteobacteria Bloom 2 Weeks Pre DiagnosisVirome Convergence 10 Days Pre OnsetTLR4 Upregulation In Premature EpitheliumBifidobacterium Absence As PreconditionHMO Mediated Colonization ResistanceFeed Forward Barrier DestructionProteobacteria BloomTLR4 Feed Forward LoopVirome ConvergenceImmature BarrierParenteral Iron OverloadBiofilmBile Acid Accumulation ASBT UpregulationMuc2 Depletion Mucosal Barrier FailureObligate Anaerobe Mucosal InvasionGut Brain Axis NDI RiskAntibiotic Driven Richness Nadir Week4

Virulence and functional enzymes

1 shared

Shared

Siderophores

Only in Long COVID

LPS Synthesis TransportAdhesion Invasion FactorsBile Salt Hydrolase (BSH)Beta-GlucuronidasePolysaccharide DegradationLPS Biosynthesis EnzymesBeta Lactamases

Only in Necrotizing Enterocolitis

LPS BiosynthesisAlpha ToxinPerfringolysin OBiofilm Formation Enzymes