Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

14%: weighted overlap
12: shared signals

First condition

Second condition

Comparison

Hashimoto's ThyroiditisandObesity

1 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

17: Hashimoto's Thyroiditis references
31: Obesity references
1: shared references

Metals elevated or accumulated

3 shared

Shared

Cadmium Lead Nickel

Only in Hashimoto's Thyroiditis

Iodine ExcessMercury Copper

Only in Obesity

Manganese Zinc Iron

Metals depleted or redistributed

0 shared

Shared

None indexed

Only in Hashimoto's Thyroiditis

Selenium Iron Zinc

Only in Obesity

Glutathione (GSH)Magnesium Barium Vanadium Titanium

Taxa enriched

0 shared

Shared

None indexed

Only in Hashimoto's Thyroiditis

Proteobacteria (Pseudomonadota)Actinobacteria (Actinomycetota)Blautia Dorea Prevotella Akkermansia muciniphila Bifidobacterium Intestinimonas Turicibacter Klebsiella pneumoniae

Only in Obesity

Escherichia coli Streptococcus Enterobacteriaceae Fusobacterium Bacteroides fragilis

Taxa depleted

5 shared

Host response elevated

2 shared

Shared

Calprotectin (S100A8/A9)Hepcidin

Only in Hashimoto's Thyroiditis

CeruloplasminAdvanced Glycation End Products

Only in Obesity

Transferrin Lipocalin-2 Lactoferrin Ferritin

Host response depleted

1 shared

Shared

Butyrate

Only in Hashimoto's Thyroiditis

Selenium Dependent GPxSelenium Dependent TrxRValeric AcidGlutathione PeroxidaseThioredoxin ReductaseSelenium Dependent Selenoproteins

Only in Obesity

Glutathione (GSH)Short-Chain Fatty Acids (SCFAs)

Ecological state

0 shared

Shared

None indexed

Only in Hashimoto's Thyroiditis

Molecular MimicryIodine Driven DysbiosisTh17 Treg ImbalanceSCFA DepletionTryptophan Metabolism DisruptionBile Acid DysmetabolismButyrate DepletionOxidative Stress

Only in Obesity

HypoxiaMetal Driven DysbiosisReduced SCFA ProductionIncreased LPSEndotoxemiaIntestinal Permeability IncreaseFermentative Metabolism Acidic MicroenvironmentMetabolic EndotoxemiaReduced Microbial DiversityIncreased Energy HarvestBile Acid DysregulationVirome Depletion

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Hashimoto's Thyroiditis

Bacterial DeiodinasesLPS EndotoxinIDO1 Kynurenine AhR PathwayThyroid Peroxidase Mimics

Only in Obesity

TMA LyaseSiderophores Nickel-UreaseNickel HydrogenaseZinc MetalloproteasesLPS Biosynthesis