Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

10%: weighted overlap
9: shared signals

First condition

Second condition

Comparison

Gastroesophageal Reflux Disease (GERD)andPremenstrual Dysphoric Disorder

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

16: Gastroesophageal Reflux Disease (GERD) references
6: Premenstrual Dysphoric Disorder references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 MetalsNickel

Only in Premenstrual Dysphoric Disorder

Copper

Metals depleted or redistributed

2 shared

Shared

Zinc Magnesium

Only in Gastroesophageal Reflux Disease (GERD)

Glutathione (GSH)Iron Calcium

Only in Premenstrual Dysphoric Disorder

None indexed

Taxa enriched

1 shared

Shared

Escherichia coli

Only in Gastroesophageal Reflux Disease (GERD)

Prevotella Pseudomonas Veillonella Leptotrichia Fusobacterium Enterobacteriaceae Bacteroides Candida albicans Fusobacterium nucleatum Mollicutes Collinsella Eggerthella

Only in Premenstrual Dysphoric Disorder

Anaerotaenia

Taxa depleted

2 shared

Host response elevated

2 shared

Shared

IL-8 (Interleukin-8 / CXCL8)TNF-alpha (Tumor Necrosis Factor Alpha)

Only in Gastroesophageal Reflux Disease (GERD)

IL 6NF KappaBIL-1beta (Interleukin-1 Beta)TLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T CellsHistamineMast Cell Mediators

Only in Premenstrual Dysphoric Disorder

Pro Inflammatory CytokinesCopper Zinc Ratio

Host response depleted

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic CellsGlutathione (GSH)

Only in Premenstrual Dysphoric Disorder

Magnesium Serotonin GABA (Gamma-Aminobutyric Acid)Allopregnanolone SensitivityButyrate

Ecological state

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationSIBOTLR2 TLR4 ActivationBidirectional Dysbiosis CycleFungal DysbiosisNickel Allergic Mucosal Inflammation

Only in Premenstrual Dysphoric Disorder

Tryptophan Kynurenine ShuntingEstrobolome DysfunctionGABA A Receptor ModulationLuteal Phase InflammationSCFA DepletionBeta Glucuronidase DysregulationEstrogen RecirculationBeta Glucuronidase ActivityCircadian Rhythm DisruptionMelatonin Amplitude Reduction

Virulence and functional enzymes

2 shared

Shared

LPS BiosynthesisBeta-Glucuronidase

Only in Gastroesophageal Reflux Disease (GERD)

Nickel-Urease NiFe-HydrogenaseArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesFungal Lipases

Only in Premenstrual Dysphoric Disorder

TryptophanaseIDO UpregulationIndoleamine 2 3 Dioxygenase