Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

12%: weighted overlap
10: shared signals

First condition

Second condition

Comparison

FibromyalgiaandType 1 Diabetes

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

9: Fibromyalgia references
20: Type 1 Diabetes references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Copper

Only in Fibromyalgia

None indexed

Only in Type 1 Diabetes

Cadmium Lead Arsenic Iron

Metals depleted or redistributed

2 shared

Taxa enriched

1 shared

Shared

Streptococcus

Only in Fibromyalgia

Eggerthella Flavonifractor Coprococcus Collinsella Eggerthella lentaCoprococcus 2

Only in Type 1 Diabetes

Bacteroides Ruminococcus gnavus Veillonella Escherichia coli Enterobacteriaceae Sutterella Akkermansia muciniphila Prevotellaceae

Taxa depleted

4 shared

Shared

Faecalibacterium prausnitzii Bifidobacterium Lachnospiraceae Roseburia

Only in Fibromyalgia

Bacteroides vulgatus Bacteroides uniformis

Only in Type 1 Diabetes

Subdoligranulum Eubacterium rectale Prevotella LactobacillusClostridium Clusters IV/XIVaBlautia Eubacterium eligens Clostridium

Host response elevated

0 shared

Shared

None indexed

Only in Fibromyalgia

CeruloplasminPro Inflammatory CytokinesCopperSerum ButyrateTNF-alpha (Tumor Necrosis Factor Alpha)IL 6

Only in Type 1 Diabetes

ZnT8 AutoantibodiesGADAIA 2AInsulin AutoantibodiesType 1 IFN SignatureTLR4 NF KB ActivationHepcidin FerritinAnti ZnT8 Autoantibodies

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Fibromyalgia

GPX3Ferritin Iron SeleniumGlutathione Peroxidase 3Serotonin

Only in Type 1 Diabetes

Treg FunctionGPR43 SCFA SignalingZinc BioavailabilityZinc Metallothionein

Ecological state

0 shared

Shared

None indexed

Only in Fibromyalgia

SCFA DepletionButyrate ParadoxBarrier DysfunctionTryptophan Kynurenine ShuntingCopper Iron Axis ImbalanceCentral SensitizationGut Barrier Dysfunction

Only in Type 1 Diabetes

Butyrate SCFA Ratio ShiftLeaky Gut Precedes OnsetBacterial Translocation To PLNMucin Layer ThinningImmunoinhibitory LPSCVB4 Microbiome SynergyTwo Step Temporal ModelMicrobiome Changes Precede AutoantibodiesBacteroidetes Firmicutes Ratio InversionGut Barrier CompromiseLPS Translocation To PLNSCFA GPR43 Axis DisruptionTreg DepletionViral Dysbiosis TriggerDevelopmental Vulnerability Window

Virulence and functional enzymes

1 shared

Shared

LPS Biosynthesis

Only in Fibromyalgia

TryptophanasePro Inflammatory Metabolite SynthesisCopper Dependent OxidasesIndoleamine 2 3 DioxygenaseNeurotoxic Metabolite Production

Only in Type 1 Diabetes

LPS Biosynthesis GenesIron Acquisition FecB IsdDEFType VI Secretion SystemsDNA Adenine MethyltransferasesBeta-Glucuronidase