WikiBiomeThe human microbiome encyclopedia
Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

19%
weighted overlap
18
shared signals
Comparison

DepressionandType 1 Diabetes

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

38
Depression references
20
Type 1 Diabetes references
0
shared references
05

Host response elevated

2 shared

Shared

HepcidinFerritin

Only in Depression

Calprotectin (S100A8/A9)Pro Inflammatory CytokinesCeruloplasmin

Only in Type 1 Diabetes

ZnT8 AutoantibodiesGADAIA 2AInsulin AutoantibodiesType 1 IFN SignatureTLR4 NF KB ActivationAnti ZnT8 Autoantibodies
07

Ecological state

0 shared

Shared

None indexed

Only in Depression

DysbiosisLeaky GutIntestinal PermeabilityEndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOSCFA DepletionHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation

Only in Type 1 Diabetes

Butyrate SCFA Ratio ShiftLeaky Gut Precedes OnsetBacterial Translocation To PLNMucin Layer ThinningImmunoinhibitory LPSCVB4 Microbiome SynergyTwo Step Temporal ModelMicrobiome Changes Precede AutoantibodiesBacteroidetes Firmicutes Ratio InversionGut Barrier CompromiseLPS Translocation To PLNSCFA GPR43 Axis DisruptionTreg DepletionViral Dysbiosis TriggerDevelopmental Vulnerability Window
08

Virulence and functional enzymes

2 shared

Shared

Beta-GlucuronidaseLPS Biosynthesis

Only in Depression

TryptophanasePro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli

Only in Type 1 Diabetes

LPS Biosynthesis GenesIron Acquisition FecB IsdDEFType VI Secretion SystemsDNA Adenine Methyltransferases