Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

15%: weighted overlap
15: shared signals

First condition

Second condition

Comparison

Type 1 DiabetesandLong COVID

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

20: Type 1 Diabetes references
18: Long COVID references
0: shared references

Metals elevated or accumulated

1 shared

Metals depleted or redistributed

2 shared

Shared

Glutathione (GSH)Selenium

Only in Type 1 Diabetes

Zinc

Only in Long COVID

Iron Copper Nickel

Taxa enriched

4 shared

Shared

Streptococcus Veillonella Escherichia coli Enterobacteriaceae

Only in Type 1 Diabetes

Bacteroides Ruminococcus gnavus Sutterella Akkermansia muciniphila Prevotellaceae

Only in Long COVID

Enterococcus Candida albicans Fusobacterium nucleatum Aspergillus Klebsiella pneumoniae

Taxa depleted

5 shared

Shared

Faecalibacterium prausnitzii Bifidobacterium Roseburia Lactobacillus Lachnospiraceae

Only in Type 1 Diabetes

Subdoligranulum Eubacterium rectale PrevotellaClostridium Clusters IV/XIVaBlautia Eubacterium eligens Clostridium

Only in Long COVID

Akkermansia muciniphila

Host response elevated

1 shared

Shared

Hepcidin

Only in Type 1 Diabetes

ZnT8 AutoantibodiesGADAIA 2AInsulin AutoantibodiesType 1 IFN SignatureTLR4 NF KB ActivationFerritinAnti ZnT8 Autoantibodies

Only in Long COVID

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)IFN-gamma (Interferon Gamma)LPS In CirculationPD 1 On CD8TIM 3 On CD8AutoantibodiesCalprotectin (S100A8/A9)Zinc In Secretions

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Type 1 Diabetes

Treg FunctionGPR43 SCFA SignalingZinc BioavailabilityZinc Metallothionein

Only in Long COVID

Regulatory T CellsNK Cell FunctionMemory B CellsSIgAButyrate SeleniumIron In Tissues

Ecological state

0 shared

Shared

None indexed

Only in Type 1 Diabetes

Butyrate SCFA Ratio ShiftLeaky Gut Precedes OnsetBacterial Translocation To PLNMucin Layer ThinningImmunoinhibitory LPSCVB4 Microbiome SynergyTwo Step Temporal ModelMicrobiome Changes Precede AutoantibodiesBacteroidetes Firmicutes Ratio InversionGut Barrier CompromiseLPS Translocation To PLNSCFA GPR43 Axis DisruptionTreg DepletionViral Dysbiosis TriggerDevelopmental Vulnerability Window

Only in Long COVID

Self Perpetuating Dysbiosis LoopAnaerobe To Aerobe ShiftSCFA CollapseBacterial Translocation EndotoxemiaGut Lung Axis DisruptionGut Brain Axis DisruptionTryptophan AhR DysmetabolismVirome Co DysbiosisMulti Kingdom DysbiosisNon Linear Recovery TrajectoryStrain Level Diversity CollapseEstrobolome DysfunctionUremic Metabolite AccumulationHypoxia CellularAerobe BloomBarrier DysfunctionBacterial TranslocationMulti Kingdom Co DysbiosisSCFA DepletionNon Linear Recovery

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Type 1 Diabetes

LPS Biosynthesis GenesIron Acquisition FecB IsdDEFType VI Secretion SystemsDNA Adenine MethyltransferasesLPS Biosynthesis

Only in Long COVID

LPS Synthesis TransportSiderophoresAdhesion Invasion FactorsBile Salt Hydrolase (BSH)Polysaccharide DegradationLPS Biosynthesis EnzymesBeta Lactamases