Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

11%: weighted overlap
9: shared signals

First condition

Second condition

Comparison

Gastroesophageal Reflux Disease (GERD)andInflammatory Bowel Disease (IBD)

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

16: Gastroesophageal Reflux Disease (GERD) references
19: Inflammatory Bowel Disease (IBD) references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 MetalsNickel

Only in Inflammatory Bowel Disease (IBD)

Iron MucosalCopper

Metals depleted or redistributed

2 shared

Taxa enriched

3 shared

Shared

Enterobacteriaceae Escherichia coli Fusobacterium nucleatum

Only in Gastroesophageal Reflux Disease (GERD)

Prevotella Pseudomonas Veillonella Leptotrichia Fusobacterium Bacteroides Candida albicans Mollicutes Collinsella Eggerthella

Only in Inflammatory Bowel Disease (IBD)

Ruminococcus gnavus

Taxa depleted

3 shared

Shared

Bifidobacterium Faecalibacterium prausnitzii Blautia

Only in Gastroesophageal Reflux Disease (GERD)

Streptococcus Lachnospiraceae Akkermansia muciniphila Actinobacteria (Actinomycetota)Methanobrevibacter Christensenellaceae

Only in Inflammatory Bowel Disease (IBD)

Roseburia Lachnospiraceae (Family)Prevotella

Host response elevated

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

IL 6IL-8 (Interleukin-8 / CXCL8)NF KappaBTNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)TLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T CellsHistamineMast Cell Mediators

Only in Inflammatory Bowel Disease (IBD)

Calprotectin (S100A8/A9)Hepcidin Lactoferrin Lipocalin-2

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic Cells

Only in Inflammatory Bowel Disease (IBD)

Alpha Defensins

Ecological state

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationSIBOTLR2 TLR4 ActivationBidirectional Dysbiosis CycleFungal DysbiosisNickel Allergic Mucosal Inflammation

Only in Inflammatory Bowel Disease (IBD)

Butyrate CollapseBarrier DysfunctionFerroptosisFirmicutes Bacteroidetes Ratio ShiftLPS TranslocationTMAO Elevation

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Nickel-Urease NiFe-HydrogenaseLPS BiosynthesisArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesFungal LipasesBeta-Glucuronidase

Only in Inflammatory Bowel Disease (IBD)

SiderophoresFimH AdhesinOuter Membrane VesiclesZinc Metalloprotease BFTMucinase