Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

11%: weighted overlap
10: shared signals

First condition

Second condition

Comparison

Gastroesophageal Reflux Disease (GERD)andEpilepsy

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

16: Gastroesophageal Reflux Disease (GERD) references
9: Epilepsy references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 MetalsNickel

Only in Epilepsy

Copper Arsenic

Metals depleted or redistributed

3 shared

Shared

Iron Zinc Magnesium

Only in Gastroesophageal Reflux Disease (GERD)

Glutathione (GSH)Calcium

Only in Epilepsy

None indexed

Taxa enriched

2 shared

Taxa depleted

2 shared

Shared

Faecalibacterium prausnitzii Blautia

Only in Gastroesophageal Reflux Disease (GERD)

Streptococcus Bifidobacterium Lachnospiraceae Akkermansia muciniphila Actinobacteria (Actinomycetota)Methanobrevibacter Christensenellaceae

Only in Epilepsy

Bacteroides Roseburia Bacteroides fragilis

Host response elevated

3 shared

Shared

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)

Only in Gastroesophageal Reflux Disease (GERD)

IL-8 (Interleukin-8 / CXCL8)NF KappaBTLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T CellsHistamineMast Cell Mediators

Only in Epilepsy

Calprotectin (S100A8/A9)

Host response depleted

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic CellsGlutathione (GSH)

Only in Epilepsy

Butyrate GABA (Gamma-Aminobutyric Acid)

Ecological state

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationSIBOTLR2 TLR4 ActivationBidirectional Dysbiosis CycleFungal DysbiosisNickel Allergic Mucosal Inflammation

Only in Epilepsy

SCFA DepletionOral Gut TranslocationMucin DegradationKynurenine Pathway ShuntingNeuroinflammation

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Nickel-Urease NiFe-HydrogenaseLPS BiosynthesisArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesFungal LipasesBeta-Glucuronidase

Only in Epilepsy

Beta GlucosidaseTryptophanaseIndoleamine 2 3 Dioxygenase Upregulation