Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

12%: weighted overlap
11: shared signals

First condition

Second condition

Comparison

FibromyalgiaandAutism Spectrum Disorder

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

9: Fibromyalgia references
32: Autism Spectrum Disorder references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Copper

Only in Fibromyalgia

None indexed

Only in Autism Spectrum Disorder

Lead Mercury Cadmium Nickel Arsenic

Metals depleted or redistributed

3 shared

Taxa enriched

0 shared

Shared

None indexed

Only in Fibromyalgia

Eggerthella Flavonifractor Coprococcus Streptococcus Collinsella Eggerthella lentaCoprococcus 2

Only in Autism Spectrum Disorder

Bacteroides Parabacteroides ClostridiumEubacterium CoprostanoligenesDesulfovibrio

Taxa depleted

3 shared

Shared

Faecalibacterium prausnitzii Bifidobacterium Lachnospiraceae

Only in Fibromyalgia

Bacteroides vulgatus Roseburia Bacteroides uniformis

Only in Autism Spectrum Disorder

Coprococcus Lactobacillus

Host response elevated

2 shared

Shared

TNF-alpha (Tumor Necrosis Factor Alpha)IL 6

Only in Fibromyalgia

CeruloplasminPro Inflammatory CytokinesCopperSerum Butyrate

Only in Autism Spectrum Disorder

Calprotectin (S100A8/A9)Lactoferrin Transferrin Hepcidin Lipocalin-2IL 1IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)NF KappaBMalondialdehydeFolate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Fibromyalgia

GPX3Ferritin Iron SeleniumGlutathione Peroxidase 3Serotonin

Only in Autism Spectrum Disorder

SulfateZinc IL-10 (Interleukin-10)TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx ActivityCu Zn SOD

Ecological state

1 shared

Shared

Gut Barrier Dysfunction

Only in Fibromyalgia

SCFA DepletionButyrate ParadoxBarrier DysfunctionTryptophan Kynurenine ShuntingCopper Iron Axis ImbalanceCentral Sensitization

Only in Autism Spectrum Disorder

Propionic Acid NeurotoxicityOxidative StressBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalGut Barrier DisruptionMis-MetallationPropionic Acid ElevationSCFA ImbalanceNeuroinflammationDevelopmental Vulnerability

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Fibromyalgia

TryptophanasePro Inflammatory Metabolite SynthesisCopper Dependent OxidasesIndoleamine 2 3 DioxygenaseLPS BiosynthesisNeurotoxic Metabolite Production

Only in Autism Spectrum Disorder

Beta-GlucuronidaseALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production