Comparative evidence
Compare conditions
Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.
- 14%
- weighted overlap
- 11
- shared signals
Comparison
DepressionandPremenstrual Dysphoric Disorder
0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.
- 38
- Depression references
- 6
- Premenstrual Dysphoric Disorder references
- 0
- shared references
Metals depleted or redistributed
2 sharedTaxa enriched
1 sharedShared
Only in Depression
Only in Premenstrual Dysphoric Disorder
Anaerotaenia
Taxa depleted
1 sharedShared
Only in Depression
Only in Premenstrual Dysphoric Disorder
Host response elevated
1 sharedShared
Pro Inflammatory Cytokines
Only in Depression
Only in Premenstrual Dysphoric Disorder
Host response depleted
1 sharedShared
Only in Depression
Only in Premenstrual Dysphoric Disorder
Ecological state
1 sharedShared
SCFA Depletion
Only in Depression
DysbiosisLeaky GutIntestinal PermeabilityEndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation
Only in Premenstrual Dysphoric Disorder
Tryptophan Kynurenine ShuntingEstrobolome DysfunctionGABA A Receptor ModulationLuteal Phase InflammationBeta Glucuronidase DysregulationEstrogen RecirculationBeta Glucuronidase ActivityCircadian Rhythm DisruptionMelatonin Amplitude Reduction
Virulence and functional enzymes
3 sharedShared
Only in Depression
Pro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli
Only in Premenstrual Dysphoric Disorder
IDO UpregulationIndoleamine 2 3 Dioxygenase