Comparative evidence
Compare conditions
Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.
- 23%
- weighted overlap
- 17
- shared signals
Comparison
DepressionandGraves' Disease
1 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.
- 38
- Depression references
- 22
- Graves' Disease references
- 1
- shared references
Metals depleted or redistributed
3 sharedTaxa enriched
3 sharedTaxa depleted
4 sharedShared
Only in Depression
Only in Graves' Disease
Host response elevated
1 sharedShared
Only in Depression
Only in Graves' Disease
Host response depleted
1 sharedShared
Glutathione Peroxidase
Only in Depression
Only in Graves' Disease
SelenoproteinsThioredoxin ReductaseDeiodinases
Ecological state
1 sharedShared
Only in Depression
DysbiosisLeaky GutEndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOSCFA DepletionHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation
Only in Graves' Disease
Th17 Treg ImbalanceMolecular MimicryEstrogen RecirculationSCFA DeficiencyLPS TranslocationBidirectional Gut Thyroid Axis
Virulence and functional enzymes
1 sharedShared
Only in Depression
TryptophanaseLPS BiosynthesisPro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli