Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

21%: weighted overlap
19: shared signals

First condition

Second condition

Comparison

DepressionandAutism Spectrum Disorder

4 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

38: Depression references
32: Autism Spectrum Disorder references
4: shared references

Metals elevated or accumulated

4 shared

Shared

Cadmium Lead Mercury Copper

Only in Depression

None indexed

Only in Autism Spectrum Disorder

Nickel Arsenic

Metals depleted or redistributed

3 shared

Taxa enriched

1 shared

Shared

Clostridium

Only in Depression

Candida albicans Bacteroides fragilis Escherichia coli Eggerthella Enterobacteriaceae Flavonifractor

Only in Autism Spectrum Disorder

Bacteroides ParabacteroidesEubacterium CoprostanoligenesDesulfovibrio

Taxa depleted

5 shared

Shared

Faecalibacterium prausnitzii Bifidobacterium Lachnospiraceae Coprococcus Lactobacillus

Only in Depression

Prevotella Dialister

Only in Autism Spectrum Disorder

None indexed

Host response elevated

2 shared

Shared

Hepcidin Calprotectin (S100A8/A9)

Only in Depression

Pro Inflammatory CytokinesCeruloplasmin Ferritin

Only in Autism Spectrum Disorder

Lactoferrin Transferrin Lipocalin-2 TNF-alpha (Tumor Necrosis Factor Alpha)IL 1IL 6IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)NF KappaBMalondialdehydeFolate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines

Host response depleted

2 shared

Shared

Zinc Glutathione (GSH)

Only in Depression

Magnesium Iron SeleniumGlutathione Peroxidase

Only in Autism Spectrum Disorder

SulfateIL-10 (Interleukin-10)TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx ActivityCu Zn SOD

Ecological state

1 shared

Shared

Neuroinflammation

Only in Depression

DysbiosisLeaky GutIntestinal Permeability EndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOSCFA DepletionHPA Axis HyperactivationBlood Brain Barrier Disruption

Only in Autism Spectrum Disorder

Gut Barrier DysfunctionPropionic Acid NeurotoxicityOxidative StressBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalGut Barrier DisruptionMis-MetallationPropionic Acid ElevationSCFA ImbalanceDevelopmental Vulnerability

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Depression

TryptophanaseLPS BiosynthesisPro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli

Only in Autism Spectrum Disorder

ALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production