Comparative evidence
Compare conditions
Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.
- 16%
- weighted overlap
- 16
- shared signals
Comparison
Crohn's DiseaseandType 1 Diabetes
1 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.
- 25
- Crohn's Disease references
- 20
- Type 1 Diabetes references
- 1
- shared references
Metals depleted or redistributed
3 sharedShared
Only in Crohn's Disease
Only in Type 1 Diabetes
None indexed
Taxa enriched
3 sharedTaxa depleted
4 sharedShared
Only in Crohn's Disease
Only in Type 1 Diabetes
BifidobacteriumSubdoligranulumEubacterium rectalePrevotellaClostridium Clusters IV/XIVaBlautiaEubacterium eligensClostridium
Host response elevated
1 sharedShared
Only in Crohn's Disease
Only in Type 1 Diabetes
ZnT8 AutoantibodiesGADAIA 2AInsulin AutoantibodiesType 1 IFN SignatureTLR4 NF KB ActivationFerritinAnti ZnT8 Autoantibodies
Host response depleted
1 sharedShared
Only in Crohn's Disease
Anti Inflammatory CytokinesAlpha Defensins
Only in Type 1 Diabetes
Ecological state
0 sharedShared
None indexed
Only in Crohn's Disease
Barrier DysfunctionLeaky GutHypoxiaBiofilmSCFA DepletionBile Acid DysmetabolismTryptophan DepletionFermentative MetabolismFerroptosisButyrate CollapseNOD2 Paneth Cell Defect
Only in Type 1 Diabetes
Butyrate SCFA Ratio ShiftLeaky Gut Precedes OnsetBacterial Translocation To PLNMucin Layer ThinningImmunoinhibitory LPSCVB4 Microbiome SynergyTwo Step Temporal ModelMicrobiome Changes Precede AutoantibodiesBacteroidetes Firmicutes Ratio InversionGut Barrier CompromiseLPS Translocation To PLNSCFA GPR43 Axis DisruptionTreg DepletionViral Dysbiosis TriggerDevelopmental Vulnerability Window
Virulence and functional enzymes
0 sharedShared
None indexed
Only in Crohn's Disease
SiderophoresZinc-MetalloproteaseIron Dependent HydrogenaseCobalt Dependent EnzymesCopper Resistance DeterminantsMucin Degrading EnzymesSiderophores EnterobactinSiderophores YersiniabactinSiderophores AerobactinZinc Metalloprotease BFTFimH AdhesinOuter Membrane VesiclesNickel-Urease
Only in Type 1 Diabetes
LPS Biosynthesis GenesIron Acquisition FecB IsdDEFType VI Secretion SystemsDNA Adenine MethyltransferasesLPS BiosynthesisBeta-Glucuronidase