Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

21%: weighted overlap
19: shared signals

First condition

Second condition

Comparison

Autism Spectrum DisorderandDepression

4 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

32: Autism Spectrum Disorder references
38: Depression references
4: shared references

Metals elevated or accumulated

4 shared

Shared

Lead Mercury Cadmium Copper

Only in Autism Spectrum Disorder

Nickel Arsenic

Only in Depression

None indexed

Metals depleted or redistributed

3 shared

Taxa enriched

1 shared

Shared

Clostridium

Only in Autism Spectrum Disorder

Bacteroides ParabacteroidesEubacterium CoprostanoligenesDesulfovibrio

Only in Depression

Candida albicans Bacteroides fragilis Escherichia coli Eggerthella Enterobacteriaceae Flavonifractor

Taxa depleted

5 shared

Shared

Coprococcus Bifidobacterium Lactobacillus Faecalibacterium prausnitzii Lachnospiraceae

Only in Autism Spectrum Disorder

None indexed

Only in Depression

Prevotella Dialister

Host response elevated

2 shared

Shared

Calprotectin (S100A8/A9)Hepcidin

Only in Autism Spectrum Disorder

Lactoferrin Transferrin Lipocalin-2 TNF-alpha (Tumor Necrosis Factor Alpha)IL 1IL 6IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)NF KappaBMalondialdehydeFolate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines

Only in Depression

Pro Inflammatory CytokinesCeruloplasmin Ferritin

Host response depleted

2 shared

Shared

Glutathione (GSH)Zinc

Only in Autism Spectrum Disorder

SulfateIL-10 (Interleukin-10)TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx ActivityCu Zn SOD

Only in Depression

Magnesium Iron SeleniumGlutathione Peroxidase

Ecological state

1 shared

Shared

Neuroinflammation

Only in Autism Spectrum Disorder

Gut Barrier DysfunctionPropionic Acid NeurotoxicityOxidative StressBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalGut Barrier DisruptionMis-MetallationPropionic Acid ElevationSCFA ImbalanceDevelopmental Vulnerability

Only in Depression

DysbiosisLeaky GutIntestinal Permeability EndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOSCFA DepletionHPA Axis HyperactivationBlood Brain Barrier Disruption

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Autism Spectrum Disorder

ALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production

Only in Depression

TryptophanaseLPS BiosynthesisPro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli