Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

11%: weighted overlap
8: shared signals

First condition

Second condition

Comparison

Anxiety DisordersandParkinson's Disease

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

12: Anxiety Disorders references
38: Parkinson's Disease references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Copper

Only in Anxiety Disorders

None indexed

Only in Parkinson's Disease

Iron Manganese Lead NickelIron Substantia NigraManganese Basal GangliaCadmium Mercury

Metals depleted or redistributed

1 shared

Taxa enriched

1 shared

Shared

Escherichia coli

Only in Anxiety Disorders

Collinsella Prevotellaceae

Only in Parkinson's Disease

Enterobacteriaceae Akkermansia muciniphila Candida albicans Porphyromonas Lactobacillus Helicobacter pylori

Taxa depleted

4 shared

Shared

Faecalibacterium prausnitzii Roseburia Blautia Lachnospiraceae

Only in Anxiety Disorders

Bifidobacterium Lactobacillus

Only in Parkinson's Disease

PrevotellaLactic Acid BacteriaCoprococcus

Host response elevated

0 shared

Shared

None indexed

Only in Anxiety Disorders

Cortisol TNF-alpha (Tumor Necrosis Factor Alpha)IL 6IL-1beta (Interleukin-1 Beta)CRP

Only in Parkinson's Disease

Hepcidin Calprotectin (S100A8/A9)Transferrin Lipocalin-2Inflammatory Cytokines TNF IL6 IL1betaFerritinTransferrin Receptor Altered

Host response depleted

0 shared

Shared

None indexed

Only in Anxiety Disorders

Butyrate Serotonin GABA (Gamma-Aminobutyric Acid)BDNF (Brain-Derived Neurotrophic Factor)

Only in Parkinson's Disease

Glutathione (GSH)Lactoferrin Short-Chain Fatty Acids (SCFAs)GPX4SelenoproteinsNeuromelanin Iron Binding Capacity

Ecological state

1 shared

Shared

SCFA Depletion

Only in Anxiety Disorders

Tryptophan Kynurenine ShuntingHPA Axis DysregulationVagal Signaling DisruptionGut Barrier Dysfunction

Only in Parkinson's Disease

HypoxiaIron Rich MicroenvironmentFunctional ShieldingBacterial TranslocationGut PermeabilityDysbiotic FermentationAcidic Microenvironment FerroptosisAlpha Synuclein Gut SeedingBlood Brain Barrier DisruptionLPS EndotoxemiaVagal Nerve PropagationHypoxia GutSiderophore Competition

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Anxiety Disorders

Indoleamine 2 3 DioxygenaseTryptophanaseLPS Biosynthesis Enzymes

Only in Parkinson's Disease

Iron SiderophoresZinc-Metalloprotease Nickel-UreaseNickel HydrogenaseMucinaseLipopolysaccharide LPSBacterial Amyloids CurliNiFe-HydrogenaseCurli AmyloidLPSSiderophores