Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

15%: weighted overlap
13: shared signals

First condition

Second condition

Comparison

Type 1 DiabetesandHashimoto's Thyroiditis

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

20: Type 1 Diabetes references
17: Hashimoto's Thyroiditis references
0: shared references

Metals elevated or accumulated

3 shared

Shared

Cadmium Lead Copper

Only in Type 1 Diabetes

Arsenic Iron

Only in Hashimoto's Thyroiditis

Iodine ExcessMercury Nickel

Metals depleted or redistributed

2 shared

Taxa enriched

1 shared

Shared

Akkermansia muciniphila

Only in Type 1 Diabetes

Bacteroides Ruminococcus gnavus Streptococcus Veillonella Escherichia coli Enterobacteriaceae Sutterella Prevotellaceae

Only in Hashimoto's Thyroiditis

Proteobacteria (Pseudomonadota)Actinobacteria (Actinomycetota)Blautia Dorea Prevotella Bifidobacterium Intestinimonas Turicibacter Klebsiella pneumoniae

Taxa depleted

5 shared

Shared

Faecalibacterium prausnitzii Bifidobacterium Roseburia Lactobacillus Lachnospiraceae

Only in Type 1 Diabetes

Subdoligranulum Eubacterium rectale PrevotellaClostridium Clusters IV/XIVaBlautia Eubacterium eligens Clostridium

Only in Hashimoto's Thyroiditis

Akkermansia muciniphila Coprococcus

Host response elevated

1 shared

Shared

Hepcidin

Only in Type 1 Diabetes

ZnT8 AutoantibodiesGADAIA 2AInsulin AutoantibodiesType 1 IFN SignatureTLR4 NF KB ActivationFerritinAnti ZnT8 Autoantibodies

Only in Hashimoto's Thyroiditis

Calprotectin (S100A8/A9)CeruloplasminAdvanced Glycation End Products

Host response depleted

0 shared

Shared

None indexed

Only in Type 1 Diabetes

Glutathione (GSH)Treg FunctionGPR43 SCFA SignalingZinc BioavailabilityZinc Metallothionein

Only in Hashimoto's Thyroiditis

Selenium Dependent GPxSelenium Dependent TrxRButyrateValeric AcidGlutathione PeroxidaseThioredoxin ReductaseSelenium Dependent Selenoproteins

Ecological state

0 shared

Shared

None indexed

Only in Type 1 Diabetes

Butyrate SCFA Ratio ShiftLeaky Gut Precedes OnsetBacterial Translocation To PLNMucin Layer ThinningImmunoinhibitory LPSCVB4 Microbiome SynergyTwo Step Temporal ModelMicrobiome Changes Precede AutoantibodiesBacteroidetes Firmicutes Ratio InversionGut Barrier CompromiseLPS Translocation To PLNSCFA GPR43 Axis DisruptionTreg DepletionViral Dysbiosis TriggerDevelopmental Vulnerability Window

Only in Hashimoto's Thyroiditis

Molecular MimicryIodine Driven DysbiosisTh17 Treg ImbalanceSCFA DepletionTryptophan Metabolism DisruptionBile Acid DysmetabolismButyrate DepletionOxidative Stress

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Type 1 Diabetes

LPS Biosynthesis GenesIron Acquisition FecB IsdDEFType VI Secretion SystemsDNA Adenine MethyltransferasesLPS Biosynthesis

Only in Hashimoto's Thyroiditis

Bacterial DeiodinasesLPS EndotoxinIDO1 Kynurenine AhR PathwayThyroid Peroxidase Mimics