Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

15%: weighted overlap
11: shared signals

First condition

Second condition

Comparison

Rheumatoid ArthritisandType 1 Diabetes

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

7: Rheumatoid Arthritis references
20: Type 1 Diabetes references
0: shared references

Metals elevated or accumulated

4 shared

Metals depleted or redistributed

0 shared

Shared

None indexed

Only in Rheumatoid Arthritis

Vitamin D Nickel

Only in Type 1 Diabetes

Zinc Glutathione (GSH)Selenium

Taxa enriched

2 shared

Shared

Escherichia coli Enterobacteriaceae

Only in Rheumatoid Arthritis

Prevotella copri Collinsella

Only in Type 1 Diabetes

Bacteroides Ruminococcus gnavus Streptococcus Veillonella Sutterella Akkermansia muciniphila Prevotellaceae

Taxa depleted

3 shared

Shared

Faecalibacterium prausnitzii Lachnospiraceae Bifidobacterium

Only in Rheumatoid Arthritis

Bacteroides fragilis

Only in Type 1 Diabetes

Roseburia Subdoligranulum Eubacterium rectale Prevotella LactobacillusClostridium Clusters IV/XIVaBlautia Eubacterium eligens Clostridium

Host response elevated

1 shared

Shared

Hepcidin

Only in Rheumatoid Arthritis

Ceruloplasmin Calprotectin (S100A8/A9)

Only in Type 1 Diabetes

ZnT8 AutoantibodiesGADAIA 2AInsulin AutoantibodiesType 1 IFN SignatureTLR4 NF KB ActivationFerritinAnti ZnT8 Autoantibodies

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Rheumatoid Arthritis

Vitamin D

Only in Type 1 Diabetes

Treg FunctionGPR43 SCFA SignalingZinc BioavailabilityZinc Metallothionein

Ecological state

0 shared

Shared

None indexed

Only in Rheumatoid Arthritis

Mucosal Origin AutoimmunityBarrier DysfunctionMolecular MimicryTh17 DominanceMetal VitD Bone AxisSoil Food Chain Exposure

Only in Type 1 Diabetes

Butyrate SCFA Ratio ShiftLeaky Gut Precedes OnsetBacterial Translocation To PLNMucin Layer ThinningImmunoinhibitory LPSCVB4 Microbiome SynergyTwo Step Temporal ModelMicrobiome Changes Precede AutoantibodiesBacteroidetes Firmicutes Ratio InversionGut Barrier CompromiseLPS Translocation To PLNSCFA GPR43 Axis DisruptionTreg DepletionViral Dysbiosis TriggerDevelopmental Vulnerability Window

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Rheumatoid Arthritis

MetalloproteinasesSiderophoresLPS Biosynthesis Enzymes

Only in Type 1 Diabetes

LPS Biosynthesis GenesIron Acquisition FecB IsdDEFType VI Secretion SystemsDNA Adenine MethyltransferasesLPS BiosynthesisBeta-Glucuronidase