Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

8%: weighted overlap
6: shared signals

First condition

Second condition

Comparison

Premenstrual Dysphoric DisorderandHashimoto's Thyroiditis

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

6: Premenstrual Dysphoric Disorder references
17: Hashimoto's Thyroiditis references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Copper

Only in Premenstrual Dysphoric Disorder

None indexed

Only in Hashimoto's Thyroiditis

Iodine ExcessCadmium Lead Mercury Nickel

Metals depleted or redistributed

1 shared

Taxa enriched

0 shared

Shared

None indexed

Only in Premenstrual Dysphoric Disorder

AnaerotaeniaEscherichia coli

Only in Hashimoto's Thyroiditis

Proteobacteria (Pseudomonadota)Actinobacteria (Actinomycetota)Blautia Dorea Prevotella Akkermansia muciniphila Bifidobacterium Intestinimonas Turicibacter Klebsiella pneumoniae

Taxa depleted

1 shared

Shared

Faecalibacterium prausnitzii

Only in Premenstrual Dysphoric Disorder

Butyricicoccus Megasphaera Parabacteroides Blautia

Only in Hashimoto's Thyroiditis

Bifidobacterium Lactobacillus Akkermansia muciniphila Roseburia Lachnospiraceae Coprococcus

Host response elevated

0 shared

Shared

None indexed

Only in Premenstrual Dysphoric Disorder

IL-8 (Interleukin-8 / CXCL8)TNF-alpha (Tumor Necrosis Factor Alpha)Pro Inflammatory CytokinesCopper Zinc Ratio

Only in Hashimoto's Thyroiditis

Calprotectin (S100A8/A9)Hepcidin CeruloplasminAdvanced Glycation End Products

Host response depleted

1 shared

Shared

Butyrate

Only in Premenstrual Dysphoric Disorder

Magnesium Serotonin GABA (Gamma-Aminobutyric Acid)Allopregnanolone Sensitivity

Only in Hashimoto's Thyroiditis

Selenium Dependent GPxSelenium Dependent TrxRValeric AcidGlutathione PeroxidaseThioredoxin ReductaseSelenium Dependent Selenoproteins

Ecological state

1 shared

Shared

SCFA Depletion

Only in Premenstrual Dysphoric Disorder

Tryptophan Kynurenine ShuntingEstrobolome DysfunctionGABA A Receptor ModulationLuteal Phase InflammationBeta Glucuronidase DysregulationEstrogen RecirculationBeta Glucuronidase ActivityCircadian Rhythm DisruptionMelatonin Amplitude Reduction

Only in Hashimoto's Thyroiditis

Molecular MimicryIodine Driven DysbiosisTh17 Treg ImbalanceTryptophan Metabolism DisruptionBile Acid DysmetabolismButyrate DepletionOxidative Stress

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Premenstrual Dysphoric Disorder

TryptophanaseIDO UpregulationLPS BiosynthesisIndoleamine 2 3 Dioxygenase

Only in Hashimoto's Thyroiditis

Bacterial DeiodinasesLPS EndotoxinIDO1 Kynurenine AhR PathwayThyroid Peroxidase Mimics