Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

16%: weighted overlap
14: shared signals

First condition

Second condition

Comparison

Gastroesophageal Reflux Disease (GERD)andHypertension

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

16: Gastroesophageal Reflux Disease (GERD) references
14: Hypertension references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Nickel

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 Metals

Only in Hypertension

Lead Cadmium

Metals depleted or redistributed

2 shared

Shared

Zinc Magnesium

Only in Gastroesophageal Reflux Disease (GERD)

Glutathione (GSH)Iron Calcium

Only in Hypertension

None indexed

Taxa enriched

3 shared

Taxa depleted

3 shared

Shared

Bifidobacterium Faecalibacterium prausnitzii Lachnospiraceae

Only in Gastroesophageal Reflux Disease (GERD)

Streptococcus Blautia Akkermansia muciniphila Actinobacteria (Actinomycetota)Methanobrevibacter Christensenellaceae

Only in Hypertension

Roseburia Mortierella

Host response elevated

2 shared

Shared

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)

Only in Gastroesophageal Reflux Disease (GERD)

IL-8 (Interleukin-8 / CXCL8)NF KappaBIL-1beta (Interleukin-1 Beta)TLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T CellsHistamineMast Cell Mediators

Only in Hypertension

HepcidinCrpIl 2r AlphaIl 18

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic Cells

Only in Hypertension

Sod

Ecological state

1 shared

Shared

Fungal Dysbiosis

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationSIBOTLR2 TLR4 ActivationBidirectional Dysbiosis CycleNickel Allergic Mucosal Inflammation

Only in Hypertension

SCFA DepletionElevated Firmicutes Bacteroidetes RatioTMAO ElevationLPS Driven EndotoxemiaBile Acid Disruption

Virulence and functional enzymes

1 shared

Shared

Fungal Lipases

Only in Gastroesophageal Reflux Disease (GERD)

Nickel-Urease NiFe-HydrogenaseLPS BiosynthesisArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesBeta-Glucuronidase

Only in Hypertension

TMA Lyases CutC CutDSiderophoresLPS Biosynthesis Enzymes