Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

11%: weighted overlap
9: shared signals

First condition

Second condition

Comparison

Gastroesophageal Reflux Disease (GERD)andGastric Cancer

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

16: Gastroesophageal Reflux Disease (GERD) references
7: Gastric Cancer references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Nickel

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 Metals

Only in Gastric Cancer

Cadmium LeadIron Luminal

Metals depleted or redistributed

1 shared

Taxa enriched

3 shared

Shared

Prevotella Escherichia coli Fusobacterium nucleatum

Only in Gastroesophageal Reflux Disease (GERD)

Pseudomonas Veillonella Leptotrichia Fusobacterium Enterobacteriaceae Bacteroides Candida albicans Mollicutes Collinsella Eggerthella

Only in Gastric Cancer

Helicobacter pylori Streptococcus

Taxa depleted

1 shared

Shared

Faecalibacterium prausnitzii

Only in Gastroesophageal Reflux Disease (GERD)

Streptococcus Bifidobacterium Blautia Lachnospiraceae Akkermansia muciniphila Actinobacteria (Actinomycetota)Methanobrevibacter Christensenellaceae

Only in Gastric Cancer

Lactobacillus

Host response elevated

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

IL 6IL-8 (Interleukin-8 / CXCL8)NF KappaBTNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)TLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T CellsHistamineMast Cell Mediators

Only in Gastric Cancer

Hepcidin Lactoferrin Calprotectin (S100A8/A9)

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic Cells

Only in Gastric Cancer

SeleniumGastric Acid

Ecological state

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationSIBOTLR2 TLR4 ActivationBidirectional Dysbiosis CycleFungal DysbiosisNickel Allergic Mucosal Inflammation

Only in Gastric Cancer

Acid Barrier LossNickel Dependent ColonizationNitrosamine ProductionCorrea Cascade ProgressionOpened Niche ColonizationChronic NF KB Inflammation

Virulence and functional enzymes

2 shared

Shared

Nickel-Urease NiFe-Hydrogenase

Only in Gastroesophageal Reflux Disease (GERD)

LPS BiosynthesisArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesFungal LipasesBeta-Glucuronidase

Only in Gastric Cancer

CagA T4SS OncoproteinSiderophoresBacterial Nitrate Reductases