Comparative evidence
Compare conditions
Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.
- 21%
- weighted overlap
- 20
- shared signals
Comparison
DepressionandCrohn's Disease
0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.
- 38
- Depression references
- 25
- Crohn's Disease references
- 0
- shared references
Metals depleted or redistributed
2 sharedTaxa enriched
4 sharedShared
Only in Depression
Only in Crohn's Disease
Taxa depleted
3 sharedShared
Only in Depression
Only in Crohn's Disease
Host response elevated
4 sharedShared
Only in Depression
Only in Crohn's Disease
Host response depleted
1 sharedShared
Only in Depression
Only in Crohn's Disease
Anti Inflammatory CytokinesAlpha Defensins
Ecological state
2 sharedShared
Leaky GutSCFA Depletion
Only in Depression
DysbiosisIntestinal PermeabilityEndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation
Only in Crohn's Disease
Barrier DysfunctionHypoxiaBiofilmBile Acid DysmetabolismTryptophan DepletionFermentative MetabolismFerroptosisButyrate CollapseNOD2 Paneth Cell Defect
Virulence and functional enzymes
0 sharedShared
None indexed
Only in Depression
TryptophanaseBeta-GlucuronidaseLPS BiosynthesisPro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli
Only in Crohn's Disease
SiderophoresZinc-MetalloproteaseIron Dependent HydrogenaseCobalt Dependent EnzymesCopper Resistance DeterminantsMucin Degrading EnzymesSiderophores EnterobactinSiderophores YersiniabactinSiderophores AerobactinZinc Metalloprotease BFTFimH AdhesinOuter Membrane VesiclesNickel-Urease