Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

15%: weighted overlap
14: shared signals

First condition

Second condition

Comparison

Colorectal CancerandInflammatory Bowel Disease (IBD)

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

36: Colorectal Cancer references
19: Inflammatory Bowel Disease (IBD) references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Copper

Only in Colorectal Cancer

Iron Zinc Cadmium Lead Nickel Arsenic Chromium

Only in Inflammatory Bowel Disease (IBD)

Iron Mucosal

Metals depleted or redistributed

3 shared

Taxa enriched

2 shared

Shared

Fusobacterium nucleatum Escherichia coli

Only in Colorectal Cancer

Fusobacterium varium Bacteroides fragilis Parvimonas micra Peptostreptococcus stomatis Clostridium symbiosum Porphyromonas gingivalis Akkermansia muciniphila Candida albicans Peptostreptococcus anaerobius Enterococcus faecalis Streptococcus gallolyticus Saccharomyces cerevisiae

Only in Inflammatory Bowel Disease (IBD)

Ruminococcus gnavus Enterobacteriaceae

Taxa depleted

3 shared

Shared

Faecalibacterium prausnitzii Roseburia Bifidobacterium

Only in Colorectal Cancer

Lachnospiraceae Prevotella copri Ruminococcus albus Dialister Lactobacillus Ruminococcus

Only in Inflammatory Bowel Disease (IBD)

Blautia Lachnospiraceae (Family)Prevotella

Host response elevated

3 shared

Shared

Calprotectin (S100A8/A9)Hepcidin Lipocalin-2

Only in Colorectal Cancer

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)Lipopolysaccharide

Only in Inflammatory Bowel Disease (IBD)

Lactoferrin

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Colorectal Cancer

IL-10 (Interleukin-10)IgATreg CellsSelenium Dependent Glutathione Peroxidase

Only in Inflammatory Bowel Disease (IBD)

Alpha Defensins

Ecological state

0 shared

Shared

None indexed

Only in Colorectal Cancer

Hypoxia BiofilmSecondary Bile Acid AccumulationFermentative Acidic MicroenvironmentEpithelial Barrier DisruptionColonic Serotonin DepletionAnaerobic DominanceSecondary Bile Acid ExcessSCFA DepletionWarburg EffectCross Kingdom DysbiosisVirome Network Disruption

Only in Inflammatory Bowel Disease (IBD)

Butyrate CollapseBarrier DysfunctionFerroptosisFirmicutes Bacteroidetes Ratio ShiftLPS TranslocationTMAO Elevation

Virulence and functional enzymes

1 shared

Shared

Siderophores

Only in Colorectal Cancer

FadAFap2LPS TLR4BFT ToxinColibactin PksUrease Glyoxalase I Beta-GlucuronidaseBFT Zinc MetalloproteaseColibactin GenotoxinFadA AdhesinFap2 LectinNAD(P)H Oxidase

Only in Inflammatory Bowel Disease (IBD)

FimH AdhesinOuter Membrane VesiclesZinc Metalloprotease BFTMucinase